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S8627

Sigma-Aldrich

Sulfacetamide

≥98.0%

Synonyme(s) :

N-(4-aminobenzènesulfonyl)acétamide

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About This Item

Formule empirique (notation de Hill):
C8H10N2O3S
Numéro CAS:
144-80-9
Poids moléculaire :
214.24
Numéro Beilstein :
981718
Numéro CE :
205-640-6
Numéro MDL:
MFCD00066501
Code UNSPSC :
51101500
ID de substance PubChem :
24899803
Nomenclature NACRES :
NA.85

Pureté

≥98.0%

Spectre d'activité de l'antibiotique

Gram-negative bacteria
Gram-positive bacteria
mycoplasma

Mode d’action

DNA synthesis | interferes

Chaîne SMILES 

CC(=O)NS(=O)(=O)c1ccc(N)cc1

InChI

1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)

Clé InChI

SKIVFJLNDNKQPD-UHFFFAOYSA-N

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Description générale

Chemical structure: sulfonamide

Application

Sulfacetamide is used to study the treatment of acne and seborrheic dermatitis. It is used to study neonatal chlamydial conjunctivitis and meningococcal conjunctivitis.

Actions biochimiques/physiologiques

Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Conditionnement

100G,500G

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H317,H335

Classification des risques

Skin Sens. 1 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

SODIUM SULFACETAMIDE FOR SEBORRHEIC DERMATITIS
STEPHEN T. WHELAN
American Journal of Diseases of Children, 71, 724-724 (1955)
E Kremer et al.
Journal of inorganic biochemistry, 100(7), 1167-1175 (2006-04-06)
The synthesis, characterization and comparative biological study of a series of antibacterial copper complexes with heterocyclic sulfonamides were reported. Two kinds of complexes were obtained with the stoichiometries [Cu(L)2] . H2O and [Cu(L)2(H2O)4] . nH2O. They were characterized by infrared
Demet Sensoy et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 72(3), 487-495 (2009-02-19)
The aim of this study was to prepare bioadhesive sulfacetamide sodium (SA) microspheres to increase their residence time on the ocular surface and to enhance their treatment efficacy on ocular keratitis. Microspheres were fabricated by spray drying method using mixture
Fatmah A M Al-Omary et al.
Bioorganic & medicinal chemistry, 18(8), 2849-2863 (2010-03-31)
A new series of 2,6-substituted-quinazolin-4-ones was designed, synthesized, and evaluated for their in vitro DHFR inhibition, antimicrobial, and antitumor activities. Compounds 22, 33-37, 39-43, and 45 proved to be active DHFR inhibitors with IC(50) range of 0.4-1.0microM. Compound 18 showed
Melanie A Miller et al.
Nucleic acids research, 42(6), 3954-3970 (2013-12-29)
The Puf family of RNA-binding proteins regulates gene expression primarily by interacting with the 3' untranslated region (3' UTR) of targeted mRNAs and inhibiting translation and/or stimulating decay. Physical association and computational analyses of yeast Puf3p identified >150 potential mRNA
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