P6254

Prednisone

≥98% (HPLC), powder, anti-inflammatory activity

• Synonyme(s) : 1,4-Pregnadiene-17α,21-diol-3,11,20-trione, 1-Cortisone, 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone
• Formule empirique (notation de Hill): C₂₁H₂₆O₅
• Numéro CAS: 53-03-2
• Poids moléculaire : 358.43
• Numéro Beilstein : 2065301
• Numéro CE : 200-160-3
• Numéro MDL: MFCD00003608
• Code UNSPSC : 12352200
• ID de substance PubChem : 24898748
• Nomenclature NACRES : NA.77

Propriétés

• product name: Prednisone, ≥98%
• Source biologique: synthetic
• Stérilité: non-sterile
• Pureté: ≥98%
• Forme: powder
• Pf: 236-238 °C (lit.)
• Solubilité: chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to light yellow
• Application(s): hematology
• Conditions d'expédition: ambient
• Température de stockage: room temp
• Chaîne SMILES: O=C1C=C[C@@]2(C)C(CC[C@]([C@@](CC[C@@]3(C(CO)=O)O)([H])[C@]3(C)C4)([H])[C@]2([H])C4=O)=C1
• InChI: 1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
• Clé InChI: XOFYZVNMUHMLCC-ZPOLXVRWSA-N
• Informations sur le gène: human ... NR3C1(2908)

Description

Application

Prednisone has been used in dimethyl sulfoxide stock suspension to inject into experimental mice and to analyze the effects of glucocorticoid steroid. It has also been used as a test drug, formulated with peanut butter to study the effects of daily administration of MIDD0301, by animal weight, organ weight and haematological analysis.

Actions biochimiques/physiologiques

Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activity. It is useful in treating many disease states and has a half-life of 3.4 to 3.8 hours in plasma. Prednisone is metabolized to prednisolone, which is physiologically active.

Caractéristiques et avantages

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Warning
• Mentions de danger: H373
• Conseils de prudence: P260 - P314 - P501
• Classification des risques: STOT RE 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges