P4680
Anti-Protein C antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Produits recommandés
Source biologique
rabbit
Conjugué
unconjugated
Forme d'anticorps
IgG fraction of antiserum
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Espèces réactives
human
Technique(s)
western blot: 1:500
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... PROC(5624)
Catégories apparentées
Description générale
Protein C (PROC) or activated protein C is a serine protease. It is expressed in the lungs. The gene encoding this protein is localized on human chromosome 2q14.
Protein C is synthesized by liver parenchymal cells as a single chain polypeptide, but in plasma, it consists mainly of a heavy chain (41 kDa) linked by a disulfide bond to a light chain (21 kDa). The plasma concentration of protein C is ~ 4 mg/mL with a half-life of about 15 hours.
Spécificité
Specifically reacts with protein C in normal pooled human plasma and shows no reaction with protein C-depleted plasma.
Immunogène
Protein C from human plasma.
Application
Anti-Protein C antibody produced in rabbit has been used to study the effects of zirconia-based stationary phase on its activity.
Anti-Protein C may be used for the immunochemical determination of protein C levels in normal and pathogenic human plasma. Determination of protein C levels can be used in the study of regulation of blood coagulation and fibrinolysis.
Actions biochimiques/physiologiques
Protein C (PROC) functions as a cytoprotective anticoagulant and has anti-inflammatory effects. PROC inactivates factors Va and VIIIa. The protein stabilizes the endothelial barrier and thereby reduces vascular permeability. It also modulates gene expression.
Protein C is a vitamin K-dependent plasma zymogen which plays an essential role in the regulation of blood coagulation. Activated protein C also enhances fibrinolysis by forming a complex with plasminogen activator inhibitor, thus allowing enhanced activity of plasminogen activator. Hereditary and acquired protein C deficiency states have been recognized to be associated with thrombosis. Homozygous severe protein C deficiency manifests in the new born by massive thrombosis and purpura fulminans. Heterozygotes for this entity usually do not manifest thrombosis.
Forme physique
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Outil de sélection de produits.
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo.
Healy LD
The Journal of Biological Chemistry, 292(21), 8616-8629 (2017)
Activation-Resistant Homozygous Protein C R229W Mutation Causing Familial Perinatal Intracranial Hemorrhage and Delayed Onset of Thrombosis
Abdulrahman Alsultan
Thrombosis Research, 143, 17-21 (2016)
The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications
Danese S, et al.
Blood, 115(6), 1121-1130 (2010)
Mechanism of protein C-dependent clot lysis: role of plasminogen activator inhibitor
Sakata Y, et al.
Blood, 68(6), 1218-1223 (1986)
Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome
Anil Sapru
Critical Care, 20, 151-151 (2016)
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique