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Principaux documents

P1742

Sigma-Aldrich

Prealbumin from human plasma

lyophilized powder

Synonyme(s) :

Thyroxine binding prealbumin, Transthyretin

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0.5 MG
236,00 €
1 MG
407,00 €
5 MG
2 440,00 €

236,00 €


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Sélectionner une taille de conditionnement

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0.5 MG
236,00 €
1 MG
407,00 €
5 MG
2 440,00 €

About This Item

Numéro CAS:
Numéro MDL:
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.25

236,00 €


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Devis pour commande en gros

Source biologique

human plasma

Niveau de qualité

Essai

≥95% (SDS-PAGE)

Forme

lyophilized powder

Technique(s)

immunoelectrophoresis: suitable
immunoprecipitation (IP): suitable

Impuretés

Infectious agents, tested

Solubilité

H2O: soluble 1 mg/mL

ε (coefficient d'extinction)

13.5 at 280 nm at 1%

Numéro d'accès UniProt

Température de stockage

−20°C

Informations sur le gène

human ... TTR(7276)

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Description générale

Human prealbumin is a product of chromosome 18. It is a serum protein, synthesized primarily in the liver.[1] It is a tetrameric protein with a molecular weight of 55 kDa. Human prealbumin is composed of four identical non-covalently bound monomers of 127 amino acid residues arranged with tetrahedral symmetry.[2]

Application

Human prealbumin was used to study reduced transthyretin expression in sera of lung cancer.[3]
Prealbumin from human plasma has been used as a positive control in immunoprecipitation[4] as a reference standard in quantitative rocket immunoelectrophoresis for quantification of cerebrospinal fluid.[5]

Actions biochimiques/physiologiques

Human prealbumin has been observed in carcinoid tumors.[1]
Prealbumin levels are indictors of malnutrition and may be modulated during inflammation.[6] It is regarded as potential marker of protein energy malnutrition (PEM) during chronic kidney failure supported dialysis.[7] Low levels of prealbumin poses high risk to heart failure (HF).[8]

Conditionnement

Package size based on protein content

Forme physique

Lyophilized powder containing sodium phosphate and NaCl

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)


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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

K Nelson et al.
International journal of cancer, 15(5), 806-814 (1975-05-15)
Spleen cells from BALB/c mice which either bore syngeneic sarcomas or were normal controls were cultured in vitro. The culture supernatants of spleen cells from tumor-bearing mice inhibited (blocked) specific cell-mediated cytotoxicity to the tumor borne by the spleen donor.
Takashi Ito et al.
Internal medicine (Tokyo, Japan), 45(20), 1173-1175 (2006-11-16)
Previously no functional study has been available for the mechanism of constipation in familial amyloid polyneuropathy (FAP). We performed a gut function test in a 78-year-old woman with transthyretin-type FAP who had severe constipation. The gut function test showed a
Haruki Koike et al.
Journal of neurology, 255(10), 1526-1533 (2008-09-30)
Through the development of gene diagnostic techniques, late-onset transthyretin Met30-associated familial amyloid polyneuropathy (FAP TTR Met30) has been shown to be more prevalent than is generally believed. To examine the electrophysiological features of late-onset FAP TTR Met30 unrelated to endemic
Prealbumin is as important as albumin in the nutritional assessment of hemodialysis patients
Chertow GM, et al.
Kidney International, 58(6), 2512-2517 (2000)
K i Misu et al.
Brain : a journal of neurology, 122 ( Pt 10), 1951-1962 (1999-10-03)
Clinicopathological and genetic features were assessed on 35 Japanese families affected by late-onset familial amyloid polyneuropathy type I (transthyretin Met30-associated familial amyloid polyneuropathy, FAP TTR Met30) whose siblings were unrelated to endemic Japanese foci. In these patients (50 years or

Questions

1–6 of 6 Questions  
  1. How long does prealbumin from human plasma (product P1742) remain stable after being dissolved in water, and at what temperature should this solution be stored?

    1 answer
    1. Stock solutions are stable for up to 2 weeks when stored refrigerated at 4°C and up to 6 months when stored in aliquots at -20°C. Avoid repeated freeze/thaw cycles.

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  2. What is the molecular weight of Product P1742, Prealbumin from human plasma?

    1 answer
    1. The molecular weight has been reported to be 54,980 Daltons. Referece: The Plasma Proteins, 2nd edition (1975) p. 60.

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  3. What is the solubility of Product P1742, Prealbumin from human plasma?

    1 answer
    1. This product is soluble in water at 1mg/mL.

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  4. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  5. What is the volume from which Product P1742, Prealbumin from human plasma, is lyophilized from?

    1 answer
    1. The starting volume is lot specific. Please contact Technical Service to obtain the exact volume of your lot of interest.

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  6. What is the purity of Product P1742, Prealbumin from human plasma?

    1 answer
    1. Information about purity can be found on the lot specific certificate of analysis.

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