O7389

Olprinone hydrochloride

Name: Olprinone hydrochloride
Brand: SIGMA

≥98% (HPLC), solid

Synonyme(s) :

1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride, Loprinone hydrochloride

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A propos de cet article

Formule empirique (notation de Hill) :

C₁₄H₁₀N₄O · HCl

Numéro CAS:

119615-63-3

Poids moléculaire :

286.72

NACRES:

NA.77

PubChem Substance ID:

24724566

UNSPSC Code:

41106305

MDL number:

MFCD01749474

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Nom du produit

Olprinone hydrochloride, ≥98% (HPLC), solid

InChI

1S/C14H10N4O.ClH/c1-9-12(6-11(7-15)14(19)17-9)10-2-3-13-16-4-5-18(13)8-10;/h2-6,8H,1H3,(H,17,19);1H

SMILES string

Cl[H].CC1=C(C=C(C#N)C(=O)N1)c2ccc3nccn3c2

InChI key

PWTBMBAQRAOAFF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

color

beige

solubility

DMSO: ≤4 mg/mL
H₂O: 6.8 mg/mL

storage temp.

2-8°C

Biochem/physiol Actions

Selective phosphodiesterase 3 (PDE3) inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Classe de stockage

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number

056K47151

056K4715

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Roles of cyclooxygenase 2 in sevoflurane- and olprinone-induced early phase of preconditioning and postconditioning against myocardial infarction in rat hearts.

Shinya Tosaka et al.

Journal of cardiovascular pharmacology and therapeutics, 16(1), 72-78 (2010-10-13)

It is known that selective cyclooxygenase 2(COX-2) inhibitors increase mortality in patients with previous myocardial infarction, and it has been suggested that COX-2 plays an important role in cardioprotection against ischemia. The current study was carried out to determine whether

[Anesthetic management of a patient with pulmonary hypertension due to a large anterior mediastinal tumor anticipated by preoperative computed tomography].

Nobuyasu Komasawa et al.

Masui. The Japanese journal of anesthesiology, 61(2), 202-205 (2012-03-15)

A 74-year-old man underwent an operation for an extremely large mediastinal tumor. Despite the lack of respiratory difficulty or distention of the jugular veins, preoperative computed tomography showed suppression of the left atrium by the huge tumor. We suspected pulmonary

Selective phosphodiesterase 3 inhibitor olprinone attenuates meconium-induced oxidative lung injury.

Daniela Mokra et al.

Pulmonary pharmacology & therapeutics, 25(3), 216-222 (2012-03-06)

Since inflammation and oxidation play a key role in the pathophysiology of neonatal meconium aspiration syndrome, various anti-inflammatory drugs have been tested in the treatment. This study evaluated whether the phosphodiesterase (PDE) 3 inhibitor olprinone can alleviate meconium-induced inflammation and

Olprinone, a specific phosphodiesterase (PDE)-III inhibitor, reduces the development of multiple organ dysfunction syndrome in mice.

Emanuela Mazzon et al.

Pharmacological research, 64(1), 68-79 (2011-01-05)

Olprinone is a specific phosphodiesterase (PDE)-III inhibitor, which has been found to have anti-inflammatory effects in addition to its main inotropic and peripheral vasodilatory effects. In the present study we investigated the effects of olprinone (0.2mg/kg, i.p.) on the development

Neuroprotective effects of olprinone after cerebral ischemia/reperfusion injury in rats.

Tiziana Genovese et al.

Neuroscience letters, 503(2), 93-99 (2011-08-30)

Olprinone hydrochloride, a specific phosphodiesterase III inhibitor, has anti-inflammatory effects in addition to its inotropic and vasodilatory effects. The purpose of this study was to examine the beneficial effects of olprinone on cerebral ischemia reperfusion injury. In the present study

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