I123
ICI 216,140
>95%, solid
Synonyme(s) :
(CH3)2CHCO-His-Trp-Ala-Val-D-Ala-His-Leu-NHCH3
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About This Item
Formule empirique (notation de Hill) :
C45H65N13O8
Numéro CAS:
Poids moléculaire :
916.08
Numéro MDL:
Code UNSPSC :
12352200
Essai
>95%
Forme
solid
Couleur
white
Température de stockage
−20°C
Chaîne SMILES
CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)C(C)C)C(C)C
Actions biochimiques/physiologiques
Potent in vivo receptor antagonist of the bombesin/gastrin releasing peptide receptor.
Code de la classe de stockage
13 - Non Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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B Campbell et al.
The American journal of physiology, 261(1 Pt 1), G16-G21 (1991-07-01)
Endocrine cells in the acid-secreting part of the avian stomach, the proventriculus, contain two forms of gastrin-releasing peptide (GRP) of 27 and 6 residues, respectively. We have examined the actions of exogenous GRP-27 and GRP-6 and endogenously released GRP in
B J Campbell et al.
Regulatory peptides, 49(3), 249-255 (1994-01-13)
The mechanisms of action of gastrin and gastrin releasing peptide (GRP) in stimulating gastric acid secretion were examined in the anaesthetized turkey. Gastrin and GRP produced dose-dependent increases in acid secretion that were inhibited by the gastrin/CCK-B antagonist CI988. The
ICI 216140 and other potent in vivo antagonist analogs of bombesin/gastrin-releasing peptide.
Camble, R., et al.
Peptides: Chemistry, Structure and Biology, Proceedings of the Eleventh American Peptide Symposium, 174-174 (1989)
R Camble et al.
Life sciences, 45(17), 1521-1527 (1989-01-01)
The GRP receptor mediated growth response in Swiss 3T3 cells has been used to identify BN/GRP antagonists. Analysis of bombesin antagonism by substance P analogues and by truncated GRP analogues revealed that deletion of the C-terminal methionine residue was important
Branimir Zogovic et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 301(5), R1486-R1494 (2011-08-19)
Bombesin, a 14 amino-acid peptide, is pressor when administered intravenously in rat and pressor and sympathoexcitatory when applied intracerebroventricularly. To determine the spinal effects of bombesin, the peptide was administered acutely in the intrathecal space at around thoracic spinal cord
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