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H8631

Sigma-Aldrich

5-Hydroxymethyl-2′-deoxyuridine

≥95% (HPLC)

Synonyme(s) :

5-HMdU, HMdUdr

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About This Item

Formule empirique (notation de Hill):
C10H14N2O6
Numéro CAS:
5116-24-5
Poids moléculaire :
258.23
Numéro CE :
225-848-0
Numéro MDL:
MFCD00047489
Code UNSPSC :
41106305
ID de substance PubChem :
24895526

Pureté

≥95% (HPLC)

Forme

powder

Solubilité

water: 50 mg/mL, clear, colorless to very faintly yellow

Température de stockage

−20°C

Chaîne SMILES 

OCC1OC(CC1O)N2C=C(CO)C(=O)NC2=O

InChI

1S/C10H14N2O6/c13-3-5-2-12(10(17)11-9(5)16)8-1-6(15)7(4-14)18-8/h2,6-8,13-15H,1,3-4H2,(H,11,16,17)

Clé InChI

IPAVKOYJGUMINP-UHFFFAOYSA-N

Application

5-Hydroxymethyl-2′-deoxyuridine (HMdUdr) is a used as a marker for oxidative nucleic acid (DNA) damage. HMdUdr may be used as an antigen to create anti-HMdUdr antibodies.

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Jin Wang et al.
Analytical chemistry, 83(6), 2201-2209 (2011-02-18)
The purpose of our study was to develop suitable methods to quantify oxidative DNA lesions in the setting of transition metal-related diseases. Transition metal-driven Fenton reactions constitute an important endogenous source of reactive oxygen species (ROS). In genetic diseases with
S Mitchell Harman et al.
Free radical biology & medicine, 35(10), 1301-1309 (2003-11-11)
To assess novel liquid chromatography/mass spectrometric methods for measuring oxidative damage to nucleic acids and lipids, we compared urinary excretion of 8-hydroxy-2'-deoxyguanosine (8-OHdG), 5-hydroxymethyl-2'-deoxyuridine (5-OHmU), and 8-hydroxyguanosine (8-OxoG), and an isoprostane, 8-iso-prostaglandin F(2)alpha (IsopF(2)alpha) in 234 healthy men (n =
I Kato et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 11(2), 143-152 (2006-06-13)
Oxidative stress has been implicated in the pathogenesis of various chronic diseases, such as cancer, cardiovascular disease and inflammatory conditions, as well as in ageing. Although a number of markers are now available, little is known about the reliability of
Kiran S Toti et al.
Bioorganic & medicinal chemistry, 21(1), 257-268 (2012-12-04)
We report the synthesis of 5'-modified thymidines (16, 18, 21, 23) and 5,5'-bis-substituted 2'-deoxyuridine analogues (30, 47) as inhibitors of thymidine monophosphate kinase of Mycobacterium tuberculosis (TMPKmt). These analogues were evaluated for their capacity to inhibit TMPKmt and solely two
Joshy Joseph et al.
Chemical communications (Cambridge, England), 46(42), 7872-7878 (2010-09-11)
The feature article is a review of the reaction of thymine in the one-electron oxidation of duplex DNA. Oxidation of DNA causes chemical reactions that result in remote damage (mutation) to a nucleobase. Normally this reaction occurs at guanine, but
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