H7158
Heat Shock Protein 60 human
recombinant, expressed in E. coli, buffered aqueous solution, ≥95% (SDS-GE)
Synonyme(s) :
HSP 60
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About This Item
Code UNSPSC :
12352202
Produits recommandés
Source biologique
human
Produit recombinant
expressed in E. coli
Essai
≥95% (SDS-GE)
Forme
buffered aqueous solution
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−70°C
Informations sur le gène
human ... HSPD1(3329)
Description générale
The gene HSP60 (heat shock protein 60) is mapped to human chromosome 2q33.1. It is a mitochondrial protein. HSP60 is induced under various stress conditions, including DNA damage, oxidative stress and heat shock. HSP60 is also referred to as HSPD1 (heat shock protein family D member 1).
Actions biochimiques/physiologiques
HSP60 (heat shock protein) works together with the cochaperonin HSP10 to allow protein folding of mitochondrial-imported proteins. It is involved in brain myelination and pathogenesis of hypomyelinating neurodegenerative disease. It also enhances proinflammatory response in cells, including macrophages, dendritic cells and endothelial cells. Mutation in HSP60 is linked with hereditary spastic paraplegia (SPG13).
Forme physique
Solution in Dulbecco′s buffered saline
Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Piotr Bodzek et al.
Journal of ovarian research, 7, 30-30 (2014-03-13)
The aim of this study was to evaluate the concentrations of IgG antibodies against Hsp60 and Hsp65 in sera of patients with ovarian cancer at various stages of clinical progress and for different histopathological types of disease. Serum samples from
Antonella Marino Gammazza et al.
Scientific reports, 5, 9434-9434 (2015-03-25)
The mitochondrial chaperonin Hsp60 is a ubiquitous molecule with multiple roles, constitutively expressed and inducible by oxidative stress. In the brain, Hsp60 is widely distributed and has been implicated in neurological disorders, including epilepsy. A role for mitochondria and oxidative
Davide Seveso et al.
Diseases of aquatic organisms, 115(1), 15-23 (2015-06-30)
Brown band disease (BrB), a virulent coral disease characterized by a dense concentration of ciliates ingesting coral tissue, is responsible for ongoing coral losses on Indo-Pacific reefs. Although several efforts have been made to identify the microbial communities associated with
S Jindal et al.
Molecular and cellular biology, 9(5), 2279-2283 (1989-05-01)
The complete cDNA for a human mitochondrial protein designated P1, which was previously identified as a microtubule-related protein, has been cloned and sequenced. The deduced amino acid sequence of P1 shows strong homology (40 to 50% identical residues and an
Daniella Magen et al.
American journal of human genetics, 83(1), 30-42 (2008-06-24)
Hypomyelinating leukodystrophies (HMLs) are disorders involving aberrant myelin formation. The prototype of primary HMLs is the X-linked Pelizaeus-Merzbacher disease (PMD) caused by mutations in PLP1. Recently, homozygous mutations in GJA12 encoding connexin 47 were found in patients with autosomal-recessive Pelizaeus-Merzbacher-like
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