H6891

7β-Hydroxycholesterol

≥95%

• Synonyme(s) : 5-Cholestene-3β,7β-diol
• Formule empirique (notation de Hill): C₂₇H₄₆O₂
• Numéro CAS: 566-27-8
• Poids moléculaire : 402.65
• Numéro MDL: MFCD00058406
• Code UNSPSC : 12352211
• ID de substance PubChem : 24895774
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Pureté: ≥95%
• Forme: powder
• Groupe fonctionnel: hydroxyl
• Conditions d'expédition: ambient
• Température de stockage: room temp
• Chaîne SMILES: [H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=C[C@@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(C)C
• InChI: 1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-25,28-29H,6-15H2,1-5H3
• Clé InChI: OYXZMSRRJOYLLO-UHFFFAOYSA-N

Description

Application

7β-hydroxycholesterol was used to study oxysterol-induced apoptosis in human endothelial cells.

Actions biochimiques/physiologiques

7β-Hydroxycholesterol is an oxysterol, the enzymatic or non-enzymatic product of cholesterol oxidation. Oxysterols are cytotoxic and induce death in monocytes, smooth muscle cells and endothelial cells. The mechanism of apoptosis induced by oxysterols may involve caspases or DNA fragmentation. Increased levels of 7β-Hydroxycholesterol correlates with increased risk of cardiovascular diseases including atherosclerosis.

Notes préparatoires

7β-Hydroxycholesterol yields clear, colorless to faint yellow solution in ethanol, with or without heating.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable