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G8671

Sigma-Aldrich

PDGFRβ(557-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonyme(s) :

CD140B, JTK12, PDGFR1

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10 μG
371,00 €

371,00 €

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10 μG
371,00 €

About This Item

Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32

371,00 €

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Produit recombinant

expressed in baculovirus infected Sf9 cells

Niveau de qualité

200

Gamme de produits

PRECISIO® Kinase

Essai

≥70% (SDS-PAGE)

Forme

buffered aqueous glycerol solution

Activité spécifique

16-22 nmol/min·mg

Poids mol.

~104 kDa

Numéro d'accès UniProt

P09619

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... PDGFRB(5159)

Description générale

PDGFRB (platelet derived growth factor receptor β) is a type III tyrosine kinase receptor, which exists as a homodimer. This receptor interacts with multiple ligands, but its main physiological ligand is PDGF-BB homodimer.[1]

Actions biochimiques/physiologiques

PDGFRB (platelet derived growth factor receptor β), upon interaction with PGDFB, regulates multiple processes such as, sclerotic disorders, wound healing and tumor angiogenesis. Gain-of-function mutation in this gene is linked with Penttinen syndrome, which is an autosomal-dominant disorder.[1] Release of PGDFB by endothelial cells results in the activation of this receptor, which is essential for the recruitment of PDGFRB+ vascular smooth muscle cells and pericytes during blood vessel formation. Loss-of-function mutation in this gene results in the neurodegenerative disorder primary familial brain calcification (PFBC).[2]

Forme physique

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Informations légales

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificats d'analyse (COA)

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P Soriano
Genes & development, 8(16), 1888-1896 (1994-08-15)
Platelet-derived growth factor, a major mitogen and chemoattractant for a number of cell types, is implicated in the processes of wound healing, tumorigenesis, and differentiation and is recognized by two receptors, alpha and beta. To begin understanding the role of
Lei Xu et al.
Cancer research, 65(13), 5711-5719 (2005-07-05)
Renal cell carcinoma is a highly malignant and often fatal disease of the kidney. It is difficult to treat, often because metastases are common at the time of presentation. Platelet-derived growth factor-D (PDGF-D) is a newly discovered member of the
Jennifer J Johnston et al.
American journal of human genetics, 97(3), 465-474 (2015-08-19)
Penttinen syndrome is a distinctive disorder characterized by a prematurely aged appearance with lipoatrophy, epidermal and dermal atrophy along with hypertrophic lesions that resemble scars, thin hair, proptosis, underdeveloped cheekbones, and marked acro-osteolysis. All individuals have been simplex cases. Exome
Michael Vanlandewijck et al.
PloS one, 10(11), e0143407-e0143407 (2015-11-26)
Primary Familial Brain Calcification (PFBC), a neurodegenerative disease characterized by progressive pericapillary calcifications, has recently been linked to heterozygous mutations in PDGFB and PDGFRB genes. Here, we functionally analyzed several of these mutations in vitro. All six analyzed PDGFB mutations

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