G3670
Galectin-8 from rat
recombinant, expressed in E. coli, ≥90% (SDS-PAGE), buffered aqueous glycerol solution
Synonyme(s) :
Gal-8, Po66 carbohydrate-binding protein, Prostate carcinoma tumor antigen 1
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About This Item
Numéro MDL:
Code UNSPSC :
12352202
Source biologique
rat
Produit recombinant
expressed in E. coli
Pureté
≥90% (SDS-PAGE)
Forme
buffered aqueous glycerol solution
Poids mol.
protein 34 kDa
Conditionnement
pkg of 100 μg
Technique(s)
cell culture | mammalian: suitable
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−20°C
Informations sur le gène
rat ... Lgals8(116641)
Description générale
Galectin-8 is one of the β-galactoside-binding lectins called galectins, which reside in the cytosol before being released in a signal sequence-independent pathway.
Actions biochimiques/physiologiques
Galectin-8 functions as a danger receptor and thus, prevents the proliferation of Salmonella. It detects host glycans found on the surface of damaged Salmonella-containing vacuoles. It also maintains the endo-lysosomal integrity. This protein prevents the adhesion of human carcinoma cells to integrin-ligand coated plates. This results in induction of apoptosis.
Galectin-8 is a family member of animal lectins which selectively binds β-galactoside residues. It is a widely expressed 34 kDa protein, which is secreted by many cell types. Galectin-8 is made of two homologous regions, each having a single carbohydrate recognition domain (CRD), linked by a short peptide. Galectin-8 acts as a physiological modulator of cell adhesion and cellular growth, and may be involved in neoplastic transformation.
Forme physique
Solution containing 20 mM Tris, pH 7.4, 1 mM DTT, 1 mM EDTA, and 30% glycerol.
Remarque sur l'analyse
The biological activity is measured by its ability to agglutinate human red cells.
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificats d'analyse (COA)
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Osamu Suzuki et al.
International journal of oncology, 46(3), 973-980 (2015-01-13)
The interaction between cell surface glycans and extracellular matrix (ECM) including galectins is known to be closely associated with tumor cell adhesion, invasion and metastasis. We analyzed the roles of cell surface sialylation or glycosylation in galectin or ECM‑mediated cell
Y Levy et al.
The Journal of biological chemistry, 276(33), 31285-31295 (2001-05-24)
The interaction of cells with the extracellular matrix regulates cell adhesion and motility. Here we demonstrate that different cell types adhere and spread when cultured in serum-free medium on immobilized galectin-8, a mammalian beta-galactoside-binding protein. At maximal doses, galectin-8 is
Teresa L M Thurston et al.
Nature, 482(7385), 414-418 (2012-01-17)
Autophagy defends the mammalian cytosol against bacterial infection. Efficient pathogen engulfment is mediated by cargo-selecting autophagy adaptors that rely on unidentified pattern-recognition or danger receptors to label invading pathogens as autophagy cargo, typically by polyubiquitin coating. Here we show in
I Camby et al.
Brain pathology (Zurich, Switzerland), 11(1), 12-26 (2001-01-06)
Galectins, a family of mammalian lectins with specificity to beta-galactosides, are involved in growth-regulatory mechanisms and cell adhesion. A relationship is assumed to exist between the levels of expression of galectins and the level of malignancy in human gliomas. A
Y R Hadari et al.
Journal of cell science, 113 ( Pt 13), 2385-2397 (2000-06-15)
The interaction of cells with the extracellular matrix regulates cell adhesion, motility, growth, survival and differentiation through integrin-mediated signal transduction. Here we demonstrate that galectin-8, a secreted mammalian (beta)-galactoside binding protein, inhibits adhesion of human carcinoma (1299) cells to plates
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