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E3526

Sigma-Aldrich

Anti-phospho-Elk-1 (pSer383) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

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About This Item

Numéro MDL:
MFCD01092332
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous glycerol solution

Espèces réactives

rat, mouse, human

Technique(s)

western blot (chemiluminescent): 1:1,000 using Elk-1 fusion protein phosphorylated with purified Erk2

Numéro d'accès UniProt

P19419

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pSer383)

Informations sur le gène

human ... ELK1(2002)
mouse ... Elk1(13712)
rat ... Elk1(314436)

Spécificité

The antibody detects Elk-1 protein only when phosphorylated at Ser383.

Immunogène

synthetic phosphopeptide corresponding to residues around phosphorylated Ser383 of human Elk-1.

Application

Anti-phospho-Elk-1 (pSer383) antibody produced in rabbit is suitable for western blotting (chemiluminescent) at a dilution of 1:1,000 using Elk-1 fusion protein phosphorylated with purified Erk2.

Actions biochimiques/physiologiques

ETS domain-containing protein Elk-1 is a protein encoded by the ELK1 gene in humans. It is a member of the Ets family of transcription factors. Elk-1 activation is important for executing its physiologic functions. Its activation is positively associated with ER and with Cyclin D1. Elk1 plays a novel role in controlling cell migration. Elk-1 is involved in a number of important cell processes through the activation of different genes in a number of normal tissues as well as in many malignancies. It is also plays a role in breast neoplasia.

Forme physique

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
SLBW4123
SLBW1123
108K1078
086K1732
016K1414

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Consulter la Bibliothèque de documents

Aggelos Laliotis et al.
Breast (Edinburgh, Scotland), 22(1), 89-95 (2012-11-07)
Recently an increased interest on Elk1 protein and its role in breast cancer evolution has been noted. This protein is an element of the Ets family of transcription factors and it has been involved in a number of important cell
Rachasak Boonhok et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(25), E3519-E3528 (2016-05-18)
IFN-γ is a major regulator of immune functions and has been shown to induce liver-stage Plasmodium elimination both in vitro and in vivo. The molecular mechanism responsible for the restriction of liver-stage Plasmodium downstream of IFN-γ remains uncertain, however. Autophagy
Zaneta Odrowaz et al.
PLoS genetics, 8(5), e1002694-e1002694 (2012-05-17)
Eukaryotic transcription factors are grouped into families and, due to their similar DNA binding domains, often have the potential to bind to the same genomic regions. This can lead to redundancy at the level of DNA binding, and mechanisms are
Jacqueline F Morris et al.
Human pathology, 44(5), 766-776 (2012-11-02)
Elk-1 is a member of the Ets family of transcription factors, which are identified by a conserved Ets DNA-binding domain that mediates transcriptional regulation at Ets sequence--containing promoters. The activation domain of Elk-1 is important for executing its physiologic functions

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