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E1282

Sigma-Aldrich

Anti-Epidermal Growth Factor Receptor antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonyme(s) :

Anti-Egfr, Anti-Erbb, Anti-Errp, Anti-Wa5

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About This Item

Numéro MDL:
MFCD00162282
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.41

Source biologique

goat

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

mouse

Technique(s)

immunohistochemistry: 5-15 μg/mL
western blot: 0.1-0.25 μg/mL

Numéro d'accès UniProt

Q01279

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

mouse ... Egfr(13649)

Immunogène

purified, NSO cell-derived recombinant mouse epidermal growth factor receptor extracellular domain.

Actions biochimiques/physiologiques

EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer.

Forme physique

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

E2760

Monoclonal Anti-Epidermal Growth Factor Receptor antibody produced in mouse, clone 29.1, ascites fluid

E3641

Epidermal Growth Factor Receptor human, buffered aqueous glycerol solution, 5,000-30,000 units/mg protein (Lowry)

E3138

Monoclonal Anti-Epidermal Growth Factor Receptor antibody produced in mouse, clone F4, ascites fluid

E2645

Epidermal Growth Factor Receptor human, lyophilized powder, ≥15,000 units/mg protein (Bradford)

E2156

Anti-EGF Receptor antibody, Mouse monoclonal, clone 225, purified from hybridoma cell culture

HPA001200

Anti-EGFR antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

E1282

Anti-Epidermal Growth Factor Receptor antibody produced in goat, affinity isolated antibody, lyophilized powder

E0532

Monoclonal Anti-Epidermal Growth Factor Receptor antibody produced in mouse, clone 102618, purified immunoglobulin, lyophilized powder

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Tai Hoon Kim et al.
FEBS letters, 585(1), 121-127 (2010-11-26)
Cuticle formation and molting are critical for the development of Caenorhabditis elegans. To understand cuticle formation more clearly, we screened for suppressors in transgenic worms that expressed dominant ROL-6 collagen proteins. The suro-1 mutant, which is mild dumpy, exhibited a
Takahiro Nakamura et al.
The Journal of clinical investigation, 124(1), 385-397 (2013-12-10)
Corneal integrity and transparency are indispensable for good vision. Cornea homeostasis is entirely dependent upon corneal stem cells, which are required for complex wound-healing processes that restore corneal integrity following epithelial damage. Here, we found that leucine-rich repeats and immunoglobulin-like
Zhilian Li et al.
Diabetes, 67(9), 1847-1857 (2018-07-01)
Previous studies by us and others have indicated that renal epidermal growth factor receptors (EGFR) are activated in models of diabetic nephropathy (DN) and that inhibition of EGFR activity protects against progressive DN in type 1 diabetes. In this study
Ming-Zhi Zhang et al.
Journal of the American Society of Nephrology : JASN, 30(9), 1659-1673 (2019-07-12)
Sex differences mediating predisposition to kidney injury are well known, with evidence indicating lower CKD incidence rates and slower decline in renal function in nondiabetic CKD for premenopausal women compared with men. However, signaling pathways involved have not been elucidated
Yan Li et al.
Diabetes, 70(2), 562-576 (2020-11-27)
Renal epidermal growth factor receptor (EGFR) signaling is activated in models of diabetic nephropathy (DN), and inhibition of the EGFR signaling pathway protects against the development of DN. We have now determined that in cultured podocytes, high glucose led to
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