D5321

D36 hydrate

≥98% (HPLC)

• Synonyme(s) : 5-(2-methoxyphenyl)-1-(2-methylpropyl)-1H-Indole-3-acetamide Hydrate
• Formule empirique (notation de Hill) : C₂₁H₂₄N₂O₂ · xH₂O
• Numéro CAS: 1228184-64-2
• Poids moléculaire : 336.43 (anhydrous basis)
• Numéro MDL: MFCD16875421
• Code UNSPSC : 51111800
• ID de substance PubChem : 329798803

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to off-white
• Solubilité: DMSO: >10 mg/mL
• Auteur: GlaxoSmithKline
• Température de stockage: 2-8°C
• Chaîne SMILES: O.COc1ccccc1-c2ccc3n(CC(C)C)cc(CC(N)=O)c3c2
• InChI: 1S/C21H24N2O2.H2O/c1-14(2)12-23-13-16(11-21(22)24)18-10-15(8-9-19(18)23)17-6-4-5-7-20(17)25-3;/h4-10,13-14H,11-12H2,1-3H3,(H2,22,24);1H2
• Clé InChI: ZERKAKHVUQMJPW-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

D36 is an androgen receptor (AR) allosteric antagonist with inverse agonist properties. D36 inhibits both wild-type and agonist-induced AR activity and antagonized AR in a hormone-refractory model.

Caractéristiques et avantages

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable