BM0023

BMS-770767

≥98% (HPLC)

• Synonyme(s) : 4-[8-(2-Chlorophenoxy)-1,2,4-triazolo[4,3-a]pyridin-3-yl]-bicyclo[2.2.1]heptan-1-ol
• Formule empirique (notation de Hill): C₁₉H₁₈ClN₃O₂
• Numéro CAS: 1875067-34-7
• Poids moléculaire : 355.82
• Code UNSPSC : 12352200
• ID de substance PubChem : 329774366
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 5 mg/mL, clear (warmed)
• Température de stockage: room temp
• Chaîne SMILES: ClC1=C(OC2=CC=CN3C2=NN=C3[C@]4(C5)CC[C@]5(O)CC4)C=CC=C1
• InChI: 1S/C19H18ClN3O2/c20-13-4-1-2-5-14(13)25-15-6-3-11-23-16(15)21-22-17(23)18-7-9-19(24,12-18)10-8-18/h1-6,11,24H,7-10,12H2/t18-,19+
• Clé InChI: HNXGIFYHJKEXNA-KDURUIRLSA-N

Description

Actions biochimiques/physiologiques

BMS-770767 is an inhibitor of 11-betahydroxysteroid dehydrogenase type I (11β-HSD1), which is a regulator of glucocorticoid activity and thought to play a possible role in metabolic syndrome. 11β-HSD1 can convert cortisol to the inactive metabolite cortisone, or catalyze the reverse reaction, converting inactive cortisone into active cortisol in cells. BMS-770767 was in clinical trials for hypercholesterolemia and Type 2 diabetes.

Caractéristiques et avantages

BMS-770767 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Informations légales

Sold for research purposes only under agreement from BMS.

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable