CD42b, encoded by the GP1BA gene, is a surface membrane glycoprotein expressed on the membrane of megakaryocytes, splenocytes and platelets. CD42b forms a part of the CD42a-d complex (also called the glycoprotein Ib-IX-V receptor) and is the surface platelet receptor for von Willebrand factor (vWF) on endothelium. CD42b is useful in differentiating acute megakaryoblastic leukemia subtype M7 (AML-M7) that are typically positive for CD41, CD42b and CD61 from acute myelofibrosis, which are CD42b negative.
Qualité
IVD
IVD
IVD
RUO
Forme physique
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and &< 0.1% Sodium Azide
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