A6604

A-350619 hydrochloride

≥98% (HPLC), solid

• Synonyme(s) : 3-[2-(4-Chlorophenylthio)phenyl]-N-(4-dimethylaminobutyl)acrylamide
• Formule empirique (notation de Hill): C₂₁H₂₅ClN₂OS · HCl
• Numéro CAS: 538368-27-3
• Poids moléculaire : 425.41
• Numéro MDL: MFCD06798332
• Code UNSPSC : 41106305
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: solid
• Couleur: white
• Pf: 175.2-176.7 °C
• Solubilité: H₂O: 23 mg/mL
• Auteur: Abbott
• Température de stockage: 2-8°C

Description

Description générale

Guanylyl cyclases are signal transduction enzyme that convert GTP to cyclic GMP. Soluble guanylate cyclase is activated by a gaseous ligand, nitric oxide.. The nitric oxide activation of soluble guanylate, resulting in GTP conversion to GMP, is important in physiological processes such as as smooth muscle relaxation, neurotransmission, inhibition of platelet aggregation and immune response. A-350619 is an activator of soluble guanylyl cyclase.

Application

A-350619 relaxes cavernosum tissue strips in a dose dependent manner with EC₅₀ of 80 μMM. Because A-350619 at 1 μMmol/kg induces penile erection in a conscious rat model, it may be useful as an alternate method of enhancing the effect of nitric oxide for the treatment of sexual dysfunction.

Actions biochimiques/physiologiques

A-350619 modulates catalytic properties of soluble guanylyl cyclase; it increases V_mas from 0.1 to 14.5 μmol/min/mg and lowers K_m from 300 to 50 μM. A-350619 activation of soluble guanylate cyclase depends on the presence of a heme moiety in the enzyme and synergy with nitric oxide.

Caractéristiques et avantages

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations légales

Sold under license from Abbott Laboratories

Informations sur la sécurité

• Pictogrammes: GHS05,GHS07,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H302,H315,H318,H335,H410
• Conseils de prudence: P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves