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426R-1

Sigma-Aldrich

STAT6 (EP325) Rabbit Monoclonal Primary Antibody

Synonyme(s) :

Signal Transducer and Activator of Transcription

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About This Item

Code UNSPSC :
12352203

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

EP325, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (426R-14)
vial of 0.1 mL concentrate Research Use Only (426R-14-RUO)
vial of 0.5 mL concentrate (426R-15)
vial of 1.0 mL concentrate (426R-16)
vial of 1.0 mL concentrate Research Use Only (426R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (426R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (426R-17)
vial of 7.0 mL pre-dilute ready-to-use (426R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (426R-18-RUO)

Fabricant/nom de marque

Cell Marque™

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

Isotype

IgG

Contrôle

solitary fibrous tumor

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

nuclear

Informations sur le gène

human ... STAT6(6778)

Catégories apparentées

Description générale

STAT6, a member of the signal transducers and activators of transcription (STAT) family, has been found to form recurrent fusions with NAB2 on chromosome 12q13 in the majority of solitary fibrous tumors. Inactivated STAT6 can be found in the form of a dimer located in the cytoplasm. STAT6 and NAB2 fusion enables cytosolic STAT6 to migrate to the nucleus and thus allowing for detection in immunohistochemical assays. NAB2-STAT6 fusion transcriptions have been reported in the majority of solitary fibrous tumors but not in meningiomas, hemangioblastomas, schwannomas, and hemangiomas. This makes STAT6 a useful marker in distinguishing solitary fibrous tumors from other morphologically similar tumors.

Qualité


IVD
IVD
IVD
RUO

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Notes préparatoires

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Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Christian Koelsche et al.
Histopathology, 65(5), 613-622 (2014-04-08)
Nuclear relocation of STAT6 has been shown in tumours with NAB2-STAT6 fusion, and has been proposed as an ancillary marker for the diagnosis of solitary fibrous tumours (SFTs). The aim of this study was to verify the utility of STAT6
Alison L Cheah et al.
Pathology, 46(5), 389-395 (2014-07-01)
Recurrent NAB2-STAT6 gene fusions have recently been identified in solitary fibrous tumour by next generation sequencing. Our aim was to examine the sensitivity and specificity of STAT6 immunohistochemistry for solitary fibrous tumour versus other morphologically similar soft tissue tumours. STAT6
Leonille Schweizer et al.
Acta neuropathologica, 125(5), 651-658 (2013-04-12)
Non-central nervous system hemangiopericytoma (HPC) and solitary fibrous tumor (SFT) are considered by pathologists as two variants of a single tumor entity now subsumed under the entity SFT. Recent detection of frequent NAB2-STAT6 fusions in both, HPC and SFT, provided

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