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T3812

Tetracaine

Name: Tetracaine
Brand: SIAL

meets USP testing specifications

Synonyme(s) :

4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester

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About This Item

Formule empirique (notation de Hill):

C₁₅H₂₄N₂O₂

Numéro CAS:

94-24-6

Poids moléculaire :

264.36

Numéro CE :

202-316-6

Numéro MDL:

MFCD00053787

Code UNSPSC :

12352202

ID de substance PubChem :

24900174

Nomenclature NACRES :

NA.21

Agence

USP/NF
meets USP testing specifications

Niveau de qualité

200

Application(s)

pharmaceutical (small molecule)

Température de stockage

2-8°C

Chaîne SMILES

CCCCNc1ccc(cc1)C(=O)OCCN(C)C

InChI

1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3

Clé InChI

GKCBAIGFKIBETG-UHFFFAOYSA-N

Informations sur le gène

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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Application

Topical ophthalmic anesthetic; used for spinal anesthesia

Actions biochimiques/physiologiques

Blocks voltage-sensitive release of Ca²⁺ from sarcoplasmic reticulum.

Pictogrammes

GHS06,GHS08

Mention d'avertissement

Danger

Mentions de danger

H301,H317,H351

Conseils de prudence

P201 - P280 - P301 + P310 + P330 - P302 + P352

Classification des risques

Acute Tox. 3 Oral - Carc. 2 - Skin Sens. 1

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.

Howard Bregman et al.

Journal of medicinal chemistry, 54(13), 4427-4445 (2011-06-04)

Clinical human genetic studies have recently identified the tetrodotoxin (TTX) sensitive neuronal voltage gated sodium channel Nav1.7 (SCN9A) as a critical mediator of pain sensitization. Herein, we report structure-activity relationships for a novel series of 2,4-diaminotriazines that inhibit hNav1.7. Optimization

Lidocaine-prilocaine cream versus tetracaine gel for procedural pain in children.

Anna Taddio et al.

The Annals of pharmacotherapy, 36(4), 687-692 (2002-03-29)

To determine the relative efficacy of lidocaine-prilocaine and tetracaine for procedural pain in children. Systematic review was performed (MEDLINE1990-June 2001) of all studies comparing the efficacy of these 2 modalities of pain relief in children undergoing painful cutaneous procedures. Search

Gain and phase of perceived virtual rotation evoked by electrical vestibular stimuli.

Ryan M Peters et al.

Journal of neurophysiology, 114(1), 264-273 (2015-05-01)

Galvanic vestibular stimulation (GVS) evokes a perception of rotation; however, very few quantitative data exist on the matter. We performed psychophysical experiments on virtual rotations experienced when binaural bipolar electrical stimulation is applied over the mastoids. We also performed analogous

A continuous flow method for estimation of drug release rates from emulsion formulations.

Lotta Salmela et al.

International journal of pharmaceutics, 472(1-2), 276-281 (2014-06-20)

We present a continuous-flow method that allows the release of drugs from submicron colloidal carriers to be estimated on a millisecond timescale. The technique is applied to the study of release of a model drug (tetracaine) from lipid emulsions, and

High-throughput log P determination by ultraperformance liquid chromatography: a convenient tool for medicinal chemists.

Yveline Henchoz et al.

Journal of medicinal chemistry, 51(3), 396-399 (2008-01-15)

Accurate determinations of lipophilicity indices benefit from recent advances in chromatographic sciences such as the launch of ultraperformance liquid chromatography (UPLC). The fast strategy presented here emerges as a powerful method suitable for high-throughput log P measurements of therapeutic compounds

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