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S0765000

Diclofenac sodium

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Diclofenac sodium salt, 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt

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About This Item

Formule empirique (notation de Hill):
C14H10Cl2NNaO2
Numéro CAS:
15307-79-6
Poids moléculaire :
318.13
Numéro MDL:
MFCD00082251
Code UNSPSC :
41116107
ID de substance PubChem :
329824440
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

diclofenac

Fabricant/nom de marque

EDQM

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

[Na+].[O-]C(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl

InChI

1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1

Clé InChI

KPHWPUGNDIVLNH-UHFFFAOYSA-M

Informations sur le gène

human ... PTGS1(5742) , PTGS2(5743)

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Diclofenac sodium EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Standard NSAID and cyclooxygenase (COX) inhibitor. Major metabolites are 4´-hydroxydiclofenac and 5´-hydroxydiclofenac. Has been used as substrate selective for CYP2C9.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

1188811

Diclofenac related compound A, United States Pharmacopeia (USP) Reference Standard

1188800

Diclofenac sodium, United States Pharmacopeia (USP) Reference Standard

D1039990

Diclofenac potassium, European Pharmacopoeia (EP) Reference Standard

18477

N-(2,6-Dichlorophenyl)-2-indolinone, analytical standard

Y0001635

Diclofenac for system suitability, European Pharmacopoeia (EP) Reference Standard

1188709

Diclofenac potassium, United States Pharmacopeia (USP) Reference Standard

BP619

Diclofenac sodium, British Pharmacopoeia (BP) Reference Standard

BP828

N-(2,6-Dichlorophenyl)-2-indolinone, British Pharmacopoeia (BP) Reference Standard

BP598

Diclofenac diethylamine, British Pharmacopoeia (BP) Reference Standard

PHR2443

Diclofenac Impurity E, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2446

Diclofenac Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2447

Diclofenac Impurity D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2445

Diclofenac Impurity C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2444

Diclofenac Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2442

Diclofenac Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2441

Diclofenac potassium, Pharmaceutical Secondary Standard; Certified Reference Material

Pictogrammes

Skull and crossbonesHealth hazardEnvironment
GHS06,GHS08,GHS09

Mention d'avertissement

Danger

Mentions de danger

H301,H361d,H372,H411

Classification des risques

Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Shahinaze A Fouad et al.
International journal of pharmaceutics, 453(2), 569-578 (2013-06-26)
Microemulsion (ME) and poloxamer microemulsion-based gel (PMBG) were developed and optimized to enhance transport of diclofenac epolamine (DE) into the skin forming in-skin drug depot for sustained transdermal delivery of drug. D-optimal mixture experimental design was applied to optimize ME
Dong Qing Zhang et al.
Environmental pollution (Barking, Essex : 1987), 181, 98-106 (2013-07-13)
A systematic approach to assess the fate of selected pharmaceuticals (carbamazepine, naproxen, diclofenac, clofibric acid and caffeine) in hydroponic mesocosms is described. The overall objective was to determine the kinetics of depletion (from solution) and plant uptake for these compounds
Rachel P L van Swelm et al.
Toxicology and applied pharmacology, 269(2), 141-149 (2013-03-20)
Diclofenac (DF) is a widely used non-steroidal anti-inflammatory drug for the treatment of rheumatic disorders, but is often associated with liver injury. We applied urinary proteomic profiling using MALDI-TOF MS to identify biomarkers for DF-induced hepatotoxicity in mice. Female CH3/HeOUJIco
L K Dodgen et al.
Environmental pollution (Barking, Essex : 1987), 182, 150-156 (2013-08-06)
Many pharmaceutical and personal care products (PPCPs) and endocrine-disrupting chemicals (EDCs) are present in reclaimed water, leading to concerns of human health risks from the consumption of food crops irrigated with reclaimed water. This study evaluated the potential for plant
R N Brogden et al.
Drugs, 20(1), 24-48 (1980-07-01)
Diclofenac sodium, a phenylacetic acid derivative, is a non-steroidal, anti-inflammatory, analgesic agent advocated for use in rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and allied conditions, and in the treatment of pain resulting from minor surgery, trauma and dysmenorrhoea. Published
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