This product is soluble in ethanol, methanol, acetone, ether, acetonitrile, and chloroform. This product is a reference standard intended for use in laboratory chemical testing, primarily per compendial monographs. This product may not be used for therapeutic or diagnostic purposes in humans or animals. Please contact your regional Technical Service group for assistance with specific applications.
PHR1092
Cyclosporine
Pharmaceutical Secondary Standard; Certified Reference Material
Synonyme(s) :
Cyclosporin A, Antibiotic S 7481F1, Cyclosporine
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500 MG
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About This Item
Formule empirique (notation de Hill) :
C62H111N11O12
Numéro CAS:
Poids moléculaire :
1202.61
Beilstein:
3647785
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24
208,00 €
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Qualité
certified reference material
pharmaceutical secondary standard
Niveau de qualité
Agence
traceable to Ph. Eur. C2163000
traceable to USP 1158504
Famille d'API
cyclosporine
CofA (certificat d'analyse)
current certificate can be downloaded
Technique(s)
HPLC: suitable
gas chromatography (GC): suitable
Application(s)
pharmaceutical (small molecule)
Format
neat
Température de stockage
-10 to -25°C
Chaîne SMILES
CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
InChI
1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
Clé InChI
PMATZTZNYRCHOR-CGLBZJNRSA-N
Informations sur le gène
human ... PPIA(5478)
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Description générale
Cyclosporine is a lipophilic immunosuppressive peptide with antifungal and anti-inflammatory properties.[1] It selectively inhibits the production of cytokines involved in T-lymphocyte activation in response to antigen stimulation.[2] It is widely used to prevent transplanted organ rejection and for the treatment of various autoimmune diseases.[3]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Application
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Cyclosporine may be used as a reference standard for the determination of cyclosporine in biological samples by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method.[4]
Cyclosporine may be used as a reference standard for the determination of cyclosporine in biological samples by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method.[4]
Actions biochimiques/physiologiques
A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
Potent immunosuppressant; inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα; blocks cytochrome c release from mitochondria.
Remarque sur l'analyse
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Autres remarques
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Note de bas de page
To see an example of a Certificate of Analysis for this material enter LRAB3757 in the slot below. This is an example certificate only and may not be the lot that you receive.
Produit(s) apparenté(s)
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 4 Oral - Carc. 1B - Repr. 1B
Code de la classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de danger pour l'eau (WGK)
WGK 3
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Certificats d'analyse (COA)
Lot/Batch Number
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Les clients ont également consulté
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To compare the positive and negative effects of tacrolimus and ciclosporin as initial treatment for renal transplant recipients. Systematic review. Reports of comparative randomised trials of tacrolimus and ciclosporin identified by searches of Medline, Embase, the Cochrane Register of Controlled
Pascal Chiari et al.
Anesthesiology, 121(2), 232-238 (2014-07-23)
Part of the myocardial damage occurring during cardiac surgery is a consequence of reperfusion injury. Cyclosporine, a potent inhibitor of the opening of the mitochondrial permeability transition pore, attenuates reperfusion injury in patients with acute ST-segment elevation myocardial infarction. This
Jacqueline S Mourer et al.
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Calcineurin inhibitors (CNIs) have an unfavorable cardiovascular risk profile in renal transplant recipients. The aim of this substudy was to assess the effects of late CNI or mycophenolate mofetil (MMF) withdrawal on ambulatory blood pressure monitoring and carotid intima media
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This material is in powder form. The purity is typically greater than 99% and is reported in the product Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate.
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