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02191

Sigma-Aldrich

Adipic acid dihydrazide

purum, ≥97.0% (NT)

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About This Item

Formule linéaire :
NH2NHCO(CH2)4CONHNH2
Numéro CAS:
1071-93-8
Poids moléculaire :
174.20
Beilstein:
973863
Numéro CE :
213-999-5
Numéro MDL:
MFCD00007614
Code UNSPSC :
12352200
ID de substance PubChem :
329747401
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Qualité

purum

Essai

≥97.0% (NT)

Pf

180-182 °C (lit.)
180-182 °C

Chaîne SMILES 

NNC(=O)CCCCC(=O)NN

InChI

1S/C6H14N4O2/c7-9-5(11)3-1-2-4-6(12)10-8/h1-4,7-8H2,(H,9,11)(H,10,12)

Clé InChI

IBVAQQYNSHJXBV-UHFFFAOYSA-N

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Application

Adipic acid dihydrazide can be used to study chemical synthesis, organic building blocks, carbonyl compounds and hydrazides. Adipic acid dihydrazide has been used in a study to show that diphtheria toxoid can be successfully employed as a carrier protein for conjugation with Salmonella O-specific polysaccharides and play an important role in facilitating adequate immune response in typhoid fever vaccines. Adipic acid dihydrazide has also been used in a study to assess the activity of the derivatives of glycoside steviolbioside from the plant Stevia rebaudiana.

Autres remarques

Bifunctional linker employed for the immobilization of carbohydrates, e.g. to MMAC resins (methyl vinyl ether, maleic anhydride co-polymer)[1][2]

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Réf. du produit
Description
Tarif

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Environment
GHS09

Mentions de danger

H411

Conseils de prudence

P273 - P391 - P501

Classification des risques

Aquatic Chronic 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

302.0 °F - closed cup

Point d'éclair (°C)

150 °C - closed cup

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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A Satoh et al.
Analytical biochemistry, 260(1), 96-102 (1998-07-02)
We have previously reported a method to immobilize protein ligands on microtiter plates coated with methyl vinyl ether-maleic anhydride copolymer (MMAC) [Isosaki, K., et al. (1992) J. Chromatogr. 597, 123-128]. In this study, we improved the MMAC method to efficiently
A Satoh et al.
Analytical biochemistry, 275(2), 231-235 (1999-12-20)
The immobilization of carbohydrates for solid-phase assays, including enzyme-linked immunosorbent assay (ELISA), is difficult because they are hydrophilic. We developed four new methods for the immobilization of oligosaccharides. ELISA plates were first coated with methyl vinyl ether-maleic anhydride copolymer (MMAC)
O Joshi et al.
Colloids and surfaces. B, Biointerfaces, 50(1), 26-35 (2006-05-09)
Heparin was modified with adipic dihydrazide and covalently linked to surface-activated silica wafers. X-ray photoelectron spectroscopy was used at each stage of derivatization and showed that successful immobilization had taken place. Surfaces were imaged with atomic force microscopy to determine
Wen-Yu Su et al.
Journal of biomaterials science. Polymer edition, 22(13), 1777-1797 (2010-09-17)
Vitrectomy is a common procedure for treating ocular-related diseases. The surgery involves removing the vitreous humor from the center of the eye, and vitreous substitutes are needed to replace the vitreous humor after vitrectomy. In the present study, we developed
Tulsidas G Shrivastav
Journal of immunoassay & immunochemistry, 24(3), 301-309 (2003-09-05)
Preparation of horseradish peroxidase (HRP) hydrazide that is HRP linked to adipic acid dihydrazide (HRP-ADH) and its use in enzyme immunoassay (EIA) is described. In this new strategy, horseradish peroxidase was conjugated to adipic acid dihydrazide using a carbodiimide coupling
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