PC420
Anti-Capsaicin Receptor (Ab-1) (824-838) Rabbit pAb
liquid, Calbiochem®
Synonyme(s) :
Anti-Vanilloid Receptor
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About This Item
Code UNSPSC :
12352203
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
purified antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
liquid
Contient
≤0.1% sodium azide as preservative
Espèces réactives
rat, mouse
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
avoid repeated freeze/thaw cycles
Isotype
IgG
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
mouse ... Trpv1(193034)
Description générale
Anti-Capsaicin Receptor (Ab-1) (824-838), rabbit polyclonal, recognizes the ~100 kDa capsaicin receptor in mouse spinal cord extract. It is validated for WB, IF & IHC in frozen and paraffin sections.
Protein A purified rabbit polyclonal antibody. Recognizes the ~100 kDa capsaicin receptor protein.
Recognizes the ~100 kDa capsaicin receptor protein in mouse spinal cord extract.
Immunogène
a synthetic peptide (EDAEVFKDSMVPGEK) corresponding to amino acids 824-838 of rat capsaicin receptor, conjugated to KLH
Application
Frozen Sections (5 g/ml, see application references)
Immunoblotting (5-10 g/ml)
Immunofluorescence (2 g/ml)
Paraffin Sections (5 g/ml; no pre-treatment required)
Conditionnement
Please refer to vial label for lot-specific concentration.
Avertissement
Toxicity: Standard Handling (A)
Remarque sur l'analyse
Positive Control
Mouse spinal cord dorsal horn
Mouse spinal cord dorsal horn
Autres remarques
Caterina, M.J., et al. 1999. Nature398, 436.
Gau, A., et al. 1999. Eur. J. Neurosci.11, 946.
Michael, G.J., and Priestley, J.V. 1999. J. Neurosci.19, 1844.
Caterina, M.J., et al. 1997. Nature389, 816.
Szallasi, A. 1994. Gen. Pharmacol.25, 223.
Beven, S., and Szolcsanyi, J. 1990. Trends Pharmacol. Sci.11, 330.
Fields, H.L. 1987. Pain (New York: McGraw-Hill).
Gau, A., et al. 1999. Eur. J. Neurosci.11, 946.
Michael, G.J., and Priestley, J.V. 1999. J. Neurosci.19, 1844.
Caterina, M.J., et al. 1997. Nature389, 816.
Szallasi, A. 1994. Gen. Pharmacol.25, 223.
Beven, S., and Szolcsanyi, J. 1990. Trends Pharmacol. Sci.11, 330.
Fields, H.L. 1987. Pain (New York: McGraw-Hill).
Immunohistochemistry was performed on mouse spinal cord sections fixed in 4% paraformaldehyde. Immunohistochemical staining results correlate well with other independent reports and in situ hybridization studies. Antibody should be titrated for optimal results in individual systems.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
nwg
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Klaus Bielefeldt et al.
American journal of physiology. Gastrointestinal and liver physiology, 291(5), G987-G997 (2006-05-27)
Recent studies suggest that the capsaicin receptor [transient receptor potential vanilloid (TRPV)1] may play a role in visceral mechanosensation. To address the potential role of TRPV1 in vagal sensory neurons, we developed a new in vitro technique allowing us to
N J Spencer et al.
Neuroscience, 153(2), 518-534 (2008-04-09)
Rodents detect visceral pain in response to noxious levels of rectal distension. However, the mechanoreceptors that innervate the rectum and respond to noxious levels of rectal distension have not been identified. Here, we have identified the mechanoreceptors of capsaicin-sensitive rectal
M Kawashima et al.
European journal of histochemistry : EJH, 56(2), e21-e21 (2012-06-13)
Transient receptor potential vanilloid subfamily member 1 (TRPV1) is activated by capsaicin, acid, and heat and mediates pain through peripheral nerves. In the tongue, TRPV1 expression has been reported also in the epithelium. This indicates a possibility that sensation is
Nathaniel A Jeske et al.
Pain, 146(3), 301-307 (2009-09-22)
Post-translational modifications on various receptor proteins have significant effects on receptor activation. For the Transient Receptor Potential family V type 1 (TRPV1) receptor, phosphorylation of certain serine/threonine amino acid residues sensitizes the receptor to activation by capsaicin and heat. Although
Chiao-Chi Chen et al.
Scientific reports, 9(1), 12348-12348 (2019-08-28)
Gout is one of the most painful disease conditions. The central mechanism of pain processing in this condition remains elusive. Cerebral blood volume (CBV) responses are faithful correlates of brain activity changes; the application of CBV-weighted functional magnetic resonance imaging
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