MABN2395

Anti-Peripherin-2 Antibody, clone 2B7

clone 2B7, from mouse

• Synonyme(s) : Retinal degeneration slow protein
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 2B7, monoclonal
• Espèces réactives: mouse, bovine
• Technique(s): immunocytochemistry: suitable; immunofluorescence: suitable; immunohistochemistry: suitable (paraffin); western blot: suitable
• Isotype: IgG1κ
• Numéro d'accès NCBI: NP_032964.1
• Numéro d'accès UniProt: P15499
• Conditions d'expédition: ambient
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: mouse ... Prph2(19133)

Description

Description générale

Peripherin-2 (UniProt: P15499; also known as Retinal degeneration slow protein) is encoded by the Prph2 (also known as Rds) gene (Gene ID: 19133) in murine species. Peripherin-2 is a multi-pass membrane glycoprotein found in the outer segment of both rod and cone photoreceptor cells. It is localized to the photoreceptor disc rim region and is required for the initial formation and subsequent maintenance of both rod and cone outer segments. It can function as an adhesion molecule for stabilization and compaction of outer segment disks and the maintenance of the curvature of the rim. Mutations Prph2 gene are reported to cause incurable retinal degeneration. Peripherin-2 can form a wide variety of covalent and non-covalent homo- and heteromeric complexes and failure to oligomerize properly can result in protein degradation and retinitis pigmentosa.

Spécificité

Clone 2B7 detects peripherin-2 in murine and bovine eye. It targets an epitope within 23 amino acids from the C-terminal end.

Immunogène

KLH-conjugated linear peptide corresponding to 23 amino acids from the C-terminal region of murine Peripherin-2.

Application

Anti-Peripherin-2, clone 2B7, Cat. No. MABN2395, is a highly specific mouse monoclonal antibody that targets Peripherin-2/RDS and has been tested in Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), and Western Blotting.

Western Blotting Analysis: A representative lot detected Peripherin-2 in Western Blotting applications (Stuck, M.W., et. al. (2014). Hum Mol Genet. 23(23):6260-74).

Immunofluorescence Analysis: A representative lot detected Peripherin-2 in Immunofluorescence applications (Chakraborty, D., et. al. (2010). Hum Mol Genet. 19(24):4799-812).

Western Blotting Analysis: A representative lot detected Peripherin-2 in Western Blotting applications (Conley, S.M., et. al. (2010). Biochemistry. 49(5):905-11).

Immunocytochemistry Analysis: A representative lot detected Peripherin-2 in Immunocytochemistry applications (Conley, S.M., et. al. (2010). Biochemistry. 49(5):905-11).

Qualité

Evaluated by Immunohistochemistry in the outer layer of photoreceptor cells of mouse eye tissue.

Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected Peripherin-2 in the outer layer of photoreceptor cells of mouse eye tissue.

Description de la cible

39.26 kDa calculated.

Forme physique

Format: Purified

Autres remarques

Concentration: Please refer to lot specific datasheet.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1