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ABN363

Sigma-Aldrich

Anti-Myelin Protein P0 Antibody

from rabbit, purified by affinity chromatography

Synonyme(s) :

Myelin protein P0, Myelin peripheral protein, MPP, Myelin protein zero

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

rat, mouse

Réactivité de l'espèce (prédite par homologie)

bovine (based on 100% sequence homology), horse (based on 100% sequence homology), human (based on 100% sequence homology)

Technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... MPZ(4359)

Description générale

Myelin protein P0 is also called Myelin peripheral protein (MPP) and Myelin protein zero (MPZ). Myelin protein P0 is found only in peripheral nervous system and is involved in the creation of an extracellular membrane face which guides the wrapping process that eventually leads to the compaction of adjacent lamellae. Myelin protein P0 is related to several disease states including Charcot-Marie-Tooth disease 1B (CMT1B), Charcot-Marie-Tooth disease 2I (CMT2I), Charcot-Marie-Tooth disease 2J (CMT2J), Adie pupil (ADIEP), Charcot-Marie-Tooth disease, dominant, intermediate type, D (CMTDID), Dejerine-Sottas syndrome (DSS), Congenital hypomyelination neuropathy (CHN), and Roussy-Levy syndrome (ROULS).

Immunogène

KLH-conjugated linear peptide corresponding to the extracellular domain of human Myelin protein P0.

Application

Anti-Myelin Protein P0 Antibody is a highly specific rabbit polyclonal antibody, that targets Myelin Protein & has been tested in western blotting & IHC (Paraffin).
Immunohistochemistry Analysis: A 1:2,000 dilution of this antibody detected Myelin protein P0 in rat spinal cord sections.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience

Qualité

Evaluated by Western Blotting in rat spinal cord tissue lysate.

Western Blotting Analysis: A 1:5,000 dilution of this antibody detected Myelin protein P0 in 10 µg of rat spinal cord tissue lysate.

Description de la cible

~30 kDa observed

Forme physique

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Ying Zou et al.
Cell & bioscience, 11(1), 210-210 (2021-12-16)
Silent information regulator 6 (SIRT6) is a mammalian homolog of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin family. Prior evidences suggested that the anti-inflammatory function of SIRT6 after spinal cord and brain injury, and it plays a crucial role in
Ramazan Üstün et al.
Experimental and therapeutic medicine, 28(3), 345-345 (2024-07-29)
Traumatic and postoperative hemorrhages are life-threatening complications. Ankaferd BloodStopper (ABS) is a potent topical hemostatic agent to stop bleeding. However, ABS is associated with nerve toxicity. The present study aimed to investigate the functional and structural neurodegenerative effects of ABS
Sandra Murphy et al.
Journal of proteomics, 191, 212-227 (2018-02-07)
The highly progressive neuromuscular disorder dystrophinopathy is triggered by primary abnormalities in the Dmd gene, which causes cytoskeletal instability and loss of sarcolemmal integrity. Comparative organellar proteomics was employed to identify sarcolemma-associated proteins with an altered concentration in dystrophic muscle
Yan Guo et al.
Signal transduction and targeted therapy, 9(1), 32-32 (2024-02-14)
The appropriate and specific response of nerve cells to various external cues is essential for the establishment and maintenance of neural circuits, and this process requires the proper recruitment of adaptor molecules to selectively activate downstream pathways. Here, we identified
Jiawei Xu et al.
Journal of neuroinflammation, 18(1), 234-234 (2021-10-17)
Plenty of macrophages are recruited to the injured nerve to play key roles in the immunoreaction and engulf the debris of degenerated axons and myelin during Wallerian degeneration, thus creating a conducive microenvironment for nerve regeneration. Recently, drugs targeting the

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