ABE601

Anti-CPEB1 Antibody

from rabbit, purified by affinity chromatography

• Synonyme(s) : Cytoplasmic polyadenylation element-binding protein 1, CPE-BP1, CPE-binding protein 1, h-CEBP, hCPEB-1
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Produit purifié par: affinity chromatography
• Espèces réactives: rat
• Réactivité de l'espèce (prédite par homologie): human (immunogen homology)
• Technique(s): western blot: suitable
• Numéro d'accès UniProt: Q9BZB8
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... CPEB1(64506)

Description

Description générale

Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1, CPEB1) is an RNA binding protein that contains an RNA-recognition motif and a zinc finger-containing region and is found in a wide range of vertebrates and invertebrates. CPEB1 forms the nucleus of a complex of factors that regulate poly(A) elongation and promotes polyadenylation-induced translation. CPEB1 mediates many diverse biological processes such as germ cell development, cell division and senescence, and synaptic plasticity. Recently, it was discovered that CPEB1 is involved in beta-catenin mRNA translation and cell migration in astrocytes as well as regulating hypoxia-inducible factor (HIF)-1 expression, demonstrating the wide range of processes in which CPEB1 plays a role. At least four isoforms of CPEB1 are known to exist.

Spécificité

This antibody recognizes the N-terminus of CPEB1.

Immunogène

Epitope: N-terminus

KLH-conjugated linear peptide corresponding to the N-terminus of human CPEB1.

Application

Detect Cytoplasmic polyadenylation element-binding protein 1 using this rabbit polyclonal antibody, Anti-CPEB1 Antibody validated for use in western blotting.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
RNA Metabolism & Binding Proteins

Qualité

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected CPEB1 in 15 µg of rat brain tissue lysate.

Description de la cible

~65 kDa observed. Uniprot describes 2 isoforms at ~54 kDa, one isoform at ~62 kDa, and one isoform at ~63 kDa Uncharacterized bands may appear in some lysates.

Forme physique

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
Rat brain tissue lysate

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable