ABE1330
Anti-FUSE-binding protein 1 Antibody
from rabbit, purified by affinity chromatography
Synonyme(s) :
Far upstream element-binding protein 1, FBP, FUSE-binding protein 1, DNA helicase V, hDH V
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Produit purifié par
affinity chromatography
Espèces réactives
human
Réactivité de l'espèce (prédite par homologie)
feline (based on 100% sequence homology), primate (based on 100% sequence homology), rat (based on 100% sequence homology), mouse (based on 100% sequence homology), horse (based on 100% sequence homology)
Technique(s)
immunocytochemistry: suitable
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... FUBP1(8880)
Description générale
FUSE-binding protein 1, also known as Far upstream element-binding protein 1 FBP, FUSE-binding protein 1, DNA helicase V, hDH V, and encoded by the gene name FUBP1, regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. FUSE may act both as activator and repressor of transcription. There are three known FUSE binding proteins (FBP1, FBP2, and FBP3). All three belong to an ancient family of single-stranded DNA binding proteins. These proteins are required for regulation of the c-myc proto-oncogene and have been shown to bind to an A/T-rich element (far-ustream element) located 1.7 kb upstream of the c-myc P2 promoter. Although their primary sequences are closely related, the FBP, FBP2, and FBP3 genes are located on different chromosomes in both mice and humans. FUSE binding proteins are believed to be multifunctional. Besides regulating the transcription of c-myc (and quite likely other targets), the FBP family has been shown to bind a variety of RNAs in vitro.
Immunogène
Epitope: Near N-terminal
KLH-conjugated linear peptide corresponding to human FUSE-binding protein 1 near the N-terminal.
Application
Immunocytochemistry Analysis: 2.0 µg/mL from a representative lot detected FUSE-binding protein 1 in HeLa and A431 cells.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Nuclear Receptors
Nuclear Receptors
This Anti-FUSE-binding protein 1 | ABE1330 antibody is validated for use in WB, IC for the detection of FUSE-binding protein 1 | ABE1330.
Qualité
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected FUSE-binding protein 1 in 10 µg of HeLa cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected FUSE-binding protein 1 in 10 µg of HeLa cell lysate.
Description de la cible
~76 kDa observed. Uncharacterized band(s) may appear in some lysates.
Forme physique
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Stockage et stabilité
Stable for 1 year at 2-8°C from date of receipt.
Autres remarques
Concentration: Please refer to lot specific datasheet.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vous ne trouvez pas le bon produit ?
Essayez notre Outil de sélection de produits.
Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Caiqi Ma et al.
Life sciences, 269, 119098-119098 (2021-01-22)
Far upstream element-binding protein 1 (FUBP1) has been shown to involve in the tumorigenesis and tumor progression of various cancers. However, the expression and function of FUBP1 in cervical carcinoma remains unknown. Transcriptional expression of FUBP1 was initially evaluated using
Ping Jiang et al.
Journal of experimental & clinical cancer research : CR, 38(1), 400-400 (2019-09-13)
Neuroblastoma (NB) is one of the deadliest paediatric solid tumours due to its rapid proliferative characteristics. Amplified copies of MYCN are considered the most important marker for the prediction of tumour relapse and progression in NB, but they were only
Haofan Yin et al.
Molecular oncology, 15(12), 3490-3512 (2021-07-22)
Distant metastasis is, unfortunately, the leading cause of death in colorectal cancer (CRC). Approximately 50% of CRC patients develop liver metastases, while 10-30% of patients develop pulmonary metastases. The occurrence of metastasis is considered to be almost exclusively driven by
Jingxin Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(20), E4604-E4612 (2018-05-02)
RG-7916 is a first-in-class drug candidate for the treatment of spinal muscular atrophy (SMA) that functions by modulating pre-mRNA splicing of the SMN2 gene, resulting in a 2.5-fold increase in survival of motor neuron (SMN) protein level, a key protein
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique