AB5532
Anti-Nitrotyrosine Antibody
serum, Chemicon®
Synonyme(s) :
NO2-Tyrosine
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Source biologique
rabbit
Forme d'anticorps
serum
Type de produit anticorps
primary antibodies
Clone
polyclonal
Réactivité de l'espèce (prédite par homologie)
all
Fabricant/nom de marque
Chemicon®
Technique(s)
ELISA: suitable
immunohistochemistry: suitable
Conditions d'expédition
dry ice
Informations sur le gène
human ... NOS1(4842)
Description générale
The cellular production of highly reactive nitrogen species derived from nitric oxide, such as peroxynitrite, nitrogen dioxide and nitryl chloride, leads to the nitration of tyrosine resides in tissue proteins. The extent of protein nitrotyrosine formation provides an index of the production of reactive nitrogen species and potential cell damage over a period of time. Nitrotyrosine can be measured by amino-acid analysis of protein hydrolysates and detected, estimated semi-quantitatively and located in cells and tissues by immunocytochemical techniques using antibodies directed against the nitrotyrosine hapten.
Spécificité
NO2-Tyrosine
The cross-reactivities were determined using an ELISA test by competition experiments with the following compounds:
Compound Cross-reactivity ratio
NO2-Tyrosine-G-BSA 1
NO-Tyr-G-BSA 1/233
Tyr-G-BSA 1/>100,000
NO2-5HT-G-BSA 1/>100,000
NO-5HT-G-BSA 1/>100,000
NO-Cys-G-BSA 1/>100,000
NO-W-G-BSA 1/>100,000
NO-His-G-BSA 1/>100,000
Abbreviations:
(G) Glutaraldehyde
(BSA) Bovine Serum Albumin
The cross-reactivities were determined using an ELISA test by competition experiments with the following compounds:
Compound Cross-reactivity ratio
NO2-Tyrosine-G-BSA 1
NO-Tyr-G-BSA 1/233
Tyr-G-BSA 1/>100,000
NO2-5HT-G-BSA 1/>100,000
NO-5HT-G-BSA 1/>100,000
NO-Cys-G-BSA 1/>100,000
NO-W-G-BSA 1/>100,000
NO-His-G-BSA 1/>100,000
Abbreviations:
(G) Glutaraldehyde
(BSA) Bovine Serum Albumin
Immunogène
NO2-Tyrosine-Glutaraldehyde-BSA
Application
Anti-Nitrotyrosine Antibody is an antibody against Nitrotyrosine for use in ELISA, IH.
Immunohistochemistry: 1:1,000-1:2,500
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Oxidative Stress
Oxidative Stress
Forme physique
Rabbit antiserum. Liquid with 0.05% sodium azide.
Stockage et stabilité
Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Informations légales
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
S Y Yao et al.
Journal of neuroimmunology, 229(1-2), 146-156 (2010-08-21)
There are currently four known isoforms of nitric oxide synthase (NOS). Of these, neuronal NOS (nNOS) is known to be present exclusively in neurons, endothelial NOS (eNOS) in vascular endothelium, while the inducible form of NOS (iNOS) is known to
Maria A Pabón et al.
JCI insight, 3(18) (2018-09-21)
Chronic obstructive pulmonary disease (COPD), associated with cigarette smoke-induced (CS-induced) emphysema, contributes significantly to the global health care burden of disease. Although chronic kidney disease (CKD) may occur in patients with COPD, the relationship between COPD and CKD remains unclear.
Usua Laresgoiti et al.
Development (Cambridge, England), 143(20), 3686-3699 (2016-11-02)
Insufficient alveolar gas exchange capacity is a major contributor to lung disease. During lung development, a population of distal epithelial progenitors first produce bronchiolar-fated and subsequently alveolar-fated progeny. The mechanisms controlling this bronchiolar-to-alveolar developmental transition remain largely unknown. We developed
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