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AB1781SP

Sigma-Aldrich

Anti-Neurotrophin 4/5 Antibody

Chemicon®, from rabbit

Synonyme(s) :

NT4/5

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

polyclonal

Espèces réactives

rat, monkey, human, mouse

Fabricant/nom de marque

Chemicon®

Technique(s)

ELISA: suitable
immunohistochemistry: suitable
western blot: suitable

Numéro d'accès NCBI

NM_006179.3

Numéro d'accès UniProt

P34130

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... NTF4(4909)

Spécificité

Neurotrophin 4 (NT4). By dot blot, less than 1% cross-reactivity against NGF, BDNF or NT3.

Immunogène

Recombinant human Neurotrophin 4 (NT4).

Application

Anti-Neurotrophin 4/5 Antibody is an antibody against Neurotrophin 4/5 for use in ELISA, WB, IH.
Immunohistochemistry: 1-2 μg/mL (see suggested protocol).

Immunoblotting: 1-2 μg/mL

ELISA: 1-2 μg/mL

Inhibition of biological activity in vitro: 1-2 μg/mL.
BIOLOGICAL ACTIVITY: Neutralizes NT4, but not other neurotrophins.

In vivo animal studies: use neat

Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Research Sub Category
Neurochemistry & Neurotrophins

Liaison

Replaces: AB1455P

Forme physique

Format: Purified
Purified immunoglobulin. Lyophilized from PBS, no preservatives. Reconstitute with 500 μL of sterile distilled water (1 mg/mL).

Stockage et stabilité

Maintain lyophilized material at -20 to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20 to -70°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

R Cabo et al.
Anatomical record (Hoboken, N.J. : 2007), 298(3), 624-629 (2014-09-19)
Some mechanoreceptors in mammals depend totally or in part on the neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4), and their receptor TrkB, for development and maintenance. These actions are presumably exerced regulating the survival of discrete sensory neurons in
Takahiro Ishimoto et al.
NPJ science of food, 8(1), 11-11 (2024-02-07)
Oral administration of the food-derived antioxidant amino acid ergothioneine (ERGO) results in its efficient distribution in the brain and enhances cognitive function. However, effect of ERGO deficiency on cognitive impairment and the underlying mechanisms remain unknown. We revealed that cognitive
Erica Hurtado et al.
Frontiers in molecular neuroscience, 10, 147-147 (2017-06-03)
The neurotrophin brain-derived neurotrophic factor (BDNF) acts via tropomyosin-related kinase B receptor (TrkB) to regulate synapse maintenance and function in the neuromuscular system. The potentiation of acetylcholine (ACh) release by BDNF requires TrkB phosphorylation and Protein Kinase C (PKC) activation.

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