565777

γ-Secretase Inhibitor XVI

The γ-Secretase Inhibitor XVI, also referenced under CAS 208255-51-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Synonyme(s) : γ-Secretase Inhibitor XVI, DAPM, N-[N-3,5-Difluorophenacetyl]-L-alanyl-S-phenylglycine Methyl Ester
• Formule empirique (notation de Hill): C₂₀H₂₀F₂N₂O₄
• Numéro CAS: 208255-51-0
• Poids moléculaire : 390.38
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: solid
• Puissance: 10 nM IC₅₀
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: DMSO: 2 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C20H20F2N2O4/c1-12(23-17(25)10-13-8-15(21)11-16(22)9-13)19(26)24-18(20(27)28-2)14-6-4-3-5-7-14/h3-9,11-12,18H,10H2,1-2H3,(H,23,25)(H,24,26)/t12-,18-/m0/s1
• Clé InChI: XAPDRNSTUYCSQC-SGTLLEGYSA-N

Description

Description générale

A cell-permeable γ-secretase inhibitor (IC₅₀ Aβ = ~10 nM in 7PA2 cells) with anti-aggregation properties. Prevents early Aβ oligomerization by selectively blocking the Aβ dimer and trimer formation.

A cell-permeable γ-secretase inhibitor that inhibits Aβ secretion (IC₅₀ ~10 nM) by 7PA2 cells (CHO cell line stably transfected with APP751 containing V717F familial Alzheimer′s disease mutation) in a dose-dependent manner. Also exhibits anti-aggregation properties by selectively blocking Aβ dimer and trimer formation and subsequently preventing early Aβ oligomerization.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
γ-secretase Aβ₄₀ in 7PA2 cells

Product does not compete with ATP.

Reversible: no

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Autres remarques

Walsh, D.M., et al. 2002. Nature 416, 535.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable