5.06047

3,3′-Diamino-4′-methoxyflavone, DD1

• Synonyme(s) : 3,3′-Diamino-4′-methoxyflavone, DD1, 3-amino-2-(3-amino-4-methoxyphenyl)-4H-chromen-4-one, p76S6 Inhibitor, DD1, Proteasome Inhibitor, DD1
• Formule empirique (notation de Hill): C₁₆H₁₄N₂O₃
• Poids moléculaire : 282.29
• Code UNSPSC : 12352200

Propriétés

• Essai: ≥98% (HPLC)
• Niveau de qualité: 200
• Forme: powder
• Puissance: 2 μM IC₅₀
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: yellow
• Solubilité: DMSO: 100 mg/mL
• Température de stockage: 2-8°C

Description

Description générale

A cell-permeable flavone derivative that arrests the proliferation of acute myeloid leukemia cells (NB4, U937, HL-60, OCI AML3), in a dose and time-dependent manner (optimum at ~20 µM and 96 h) and blocks the colony formation in samples from acute myeloid leukemia patients, without affecting normal blood cells. Shown to reduce mitochondrial membrane potential and Bad phosphorylation (at Ser136), induce Bax and caspase 3, 8, and 9 activation in U937 cells. Does not affect the phosphorylation of Akt1, but significantly reduces the expression and phosphorylation of p70S6 kinase in U937 cells. Reported to inhibit the chymotrypsin-like activity of proteasome (IC₅₀ = 2.0 µM) and this effect is synergistic with bortezomib (Cat. No. 504314).

Actions biochimiques/physiologiques

Cell permeable: yes

Reversible: yes

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Piedfer. M., et al, 2013. Biochim. Biophys. Acta.1833,1316
Quiney, C., et al, 2004. Leuk. Res.28, 851.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable