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04-486

Sigma-Aldrich

Anti-RhoG Antibody, clone 1F3 B3 E5

clone 1F3 B3 E5, Upstate®, from mouse

Synonyme(s) :

ARHG, RHOG ras homolog gene family, member G (rho G), MGC125835, MGC125836

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

1F3 B3 E5, monoclonal

Espèces réactives

mouse, rat, human

Fabricant/nom de marque

Upstate®

Technique(s)

western blot: suitable

Isotype

IgG2bκ

Numéro d'accès NCBI

NM_001665

Numéro d'accès UniProt

P84095

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... RHOG(391)

Description générale

RhoG (ARGH) is a member of the Ras super-family of small G-proteins and a member of the Rac subfamily of Rho Family of GTPases. RhoG is a small G-protein (GTPase) who is activated by a GEF (guanine nucleotide exchange factor). The GEF displaces GDP from the binding site of RhoG and allows GTP to bind in it place rendering the protein active. This active RhoG binds downstream effector molecules that include ELMO and DOCK180. RhoG then cleaves GTP to GDP making it inactive. RhoG is believed to be crucial for integrin-mediated Rac activation and cell spreading. RhoG is believed to be active upstream of Rac and work independently of Rac.

Spécificité

Recognizes RhoG

Immunogène

KLH synthetic peptide encompassing amino acids CQQDGVKEVFAEAVRAVLNPT (RhoG 160-180)

Application

Anti-RhoG Antibody, clone 1F3 B3 E5 is an antibody against RhoG for use in WB.

Qualité

Routinely evaluated by western blot on NIH/3T3 cell lysate.

Description de la cible

21 kDa

Forme physique

Format: Purified
Purified mouse monoclonal IgG2b in storage buffer containing PBS with 0.05% sodium azide.

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.
Moshfegh, Y; Bravo-Cordero, JJ; Miskolci, V; Condeelis, J; Hodgson, L
Nature Cell Biology null
Aneta Kwiatkowska et al.
Molecular cancer, 11, 65-65 (2012-09-13)
The invasion of glioblastoma cells into regions of the normal brain is a critical factor that limits current therapies for malignant astrocytomas. Previous work has identified roles for the Rho family guanine nucleotide exchange factors Trio and Vav3 in glioblastoma
Sergi Marco et al.
Nature communications, 12(1), 6829-6829 (2021-11-26)
Signals are relayed from receptor tyrosine kinases (RTKs) at the cell surface to effector systems in the cytoplasm and nucleus, and coordination of this process is important for the execution of migratory phenotypes, such as cell scattering and invasion. The
Kristin Franke et al.
The EMBO journal, 31(13), 2908-2921 (2012-05-17)
The small GTPase RhoG plays a central role in actin remodelling during diverse biological processes such as neurite outgrowth, cell migration, phagocytosis of apoptotic cells, and the invasion of pathogenic bacteria. Although it is known that RhoG stimulates neurite outgrowth

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