800811O

18:1 DG

Avanti Research^™ - A Croda Brand

• Synonyme(s) : 1-2-di-(9Z-octadecenoyl)-sn-glycerol; DG(18:1(9Z)/18:1(9Z)/0:0); DOG
• Formule empirique (notation de Hill) : C₃₉H₇₂O₅
• Numéro CAS: 24529-88-2
• Poids moléculaire : 620.99
• Numéro MDL: MFCD00148866
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.25

Propriétés

• Description: 1-2-dioleoyl-sn-glycerol, neat oil
• Essai: >99% (TLC)
• Forme: liquid
• Conditionnement: pkg of 1 × 10 mg (with screw cap (800811O-10mg)); pkg of 2 × 100 mg (with screw cap (800811O-200mg)); pkg of 5 × 100 mg (with screw cap 800811O-500mg); pkg of 1 × 25 mg (with screw cap (800811O-25mg))
• Fabricant/nom de marque: Avanti Research^™ - A Croda Brand
• Type de lipide: neutral glycerides; neutral lipids
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: O([C@H](COC(=O)CCCCCCC\C=C\CCCCCCCC)CO)C(=O)CCCCCCC\C=C/CCCCCCCC
• InChI: 1S/C39H72O5/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(41)43-36-37(35-40)44-39(42)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,37,40H,3-16,21-36H2,1-2H3/b19-17+,20-18-/t37-/m0/s1
• Clé InChI: AFSHUZFNMVJNKX-CSWDEDFYSA-N

Description

Description générale

Diacylglycerol/diglyceride (DAG) is a glycerolipid, that is located at the plasma membrane.[1] It is made up of two fatty acid chains that are covalently attached to a single glycerol molecule with the help of an ester linkage.[2]

Application

18:1 DG has been used as a diacyl-glycerol source in diacylglycerol O-acyltransferase 1 (DGAT1) assay.[3] It has also been used as substrate to assess compounds as potential inhibitors of DGAT-1 in DGAT-1 enzyme assay.[4] It is suitable to use in lipid-protein overlay screen assay with the recombinant protein His-AtROP6.

Conditionnement

5 mL PTFE Vial with Screw Cap (800811O-10mg)

5 mL PTFE Vial with Screw Cap (800811O-200mg)

5 mL PTFE Vial with Screw Cap (800811O-25mg)

5 mL PTFE Vial with Screw Cap (800811O-500mg)

Stockage et stabilité

Diacylglycerols are conveniently stored in chloroform solutions in glass vials with PTFE-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.

Autres remarques

Delivery to cells:
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.

Effective concentration:
Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.

Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable