919950

3-(([1,1′-Biphenyl]-4-ylmethyl)thio)-6-methyl-1,2,4,5-tetrazine

>98%

• Synonyme(s) : b-Tz, Minimal tetrazine
• Formule empirique (notation de Hill) : C₁₆H₁₄N₄S
• Numéro CAS: 2378619-75-9
• Poids moléculaire : 294.37
• Numéro MDL: MFCD33021752
• Code UNSPSC : 12352106
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 100
• Essai: >98%
• Forme: powder
• Capacité de réaction: reaction type: click chemistry
• Chaîne SMILES: S(Cc2ccc(cc2)c3ccccc3)c1nnc(nn1)C
• Clé InChI: YATUIOCNNCZRCH-UHFFFAOYSA-N

Description

Application

3-(([1,1′-Biphenyl]-4-ylmethyl)thio)-6-methyl-1,2,4,5-tetrazine (b-Tz) is a minimal tetrazine derivative capable of undergoing [4+2] Diels-Alder cycloaddition reactions with strained alkenes, which makes it highly useful in bioorthogonal labeling and cell detection applications. Tetrazines are often incorporated into chemical probes or other small-molecule tools using linkers that may impact physicochemical properties or the performance of the resulting conjugate product. Here, Lambert et al demonstrated the linker-free incorporation of b-Tz via silver-mediated Liebeskind-Srogl cross-coupling with a variety of aryl and heteroaryl boronic acids. This ″minimal″ tetrazine approach will facilitate the introduction of tetrazine into diverse complex molecules and improved probes for live-cell imaging and in vivo chemistry.

Supporting products
PdCl₂(dppf): 697230
Ag₂O: 226831

Autres remarques

Installation of Minimal Tetrazines through Silver-Mediated Liebeskind-Srogl Coupling with Arylboronic Acids

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable