532703

1-Bromo-4-chloro-2-fluorobenzene

98%

• Formule linéaire : BrC₆H₃(Cl)F
• Numéro CAS: 1996-29-8
• Poids moléculaire : 209.44
• Numéro MDL: MFCD00079708
• Code UNSPSC : 12352100
• ID de substance PubChem : 24877906
• Nomenclature NACRES : NA.22

Propriétés

• Essai: 98%
• Indice de réfraction: n20/D 1.556 (lit.)
• pb: 91-92 °C/20 mmHg (lit.)
• Densité: 1.678 g/mL at 25 °C (lit.)
• Chaîne SMILES: Fc1cc(Cl)ccc1Br
• InChI: 1S/C6H3BrClF/c7-5-2-1-4(8)3-6(5)9/h1-3H
• Clé InChI: FPNVMCMDWZNTEU-UHFFFAOYSA-N

Description

Description générale

1-Bromo-4-chloro-2-fluorobenzene is a polyhalo substituted benzene. It undergoes Suzuki coupling with 2-cyanoarylboronic esters to form the corresponding biphenyls. These biphenyls are the precursors for synthesizing 6-substituted phenanthridines.† The enthalpy of vaporization at boiling point (467.15K) of 1-bromo-4-chloro-2-fluorobenzene is 40.737kjoule/mol.{4}

Application

1-Bromo-4-chloro-2-fluorobenzene may be used in the preparation of benzonorbornadiene derivative. It may also be used as a starting material in the multi-step synthesis of AZD3264, an IKK2 (inhibitor of nuclear factor κ-B kinase-2) inhibitor.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 198.0 °F - closed cup
• Point d'éclair (°C): 92.2 °C - closed cup
• Équipement de protection individuelle: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)