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484628

Benztropine mesylate

Name: Benztropine mesylate
Brand: ALDRICH

95%

Synonyme(s) :

Benztropine methanesulfonate

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About This Item

Formule empirique (notation de Hill):

C₂₁H₂₅NO

Numéro CAS:

132-17-2

Poids moléculaire :

307.43

Numéro CE :

205-048-8

Numéro MDL:

MFCD00074784

Code UNSPSC :

12352103

Essai

95%

Pf

135 °C (lit.)

Chaîne SMILES

CS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(c3ccccc3)c4ccccc4

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Pictogrammes

GHS06

Mention d'avertissement

Danger

Mentions de danger

H302,H311 + H331

Conseils de prudence

P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P311

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificats d'analyse (COA)

Lot/Batch Number

20511TR

13802TR

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Consulter la Bibliothèque de documents

The dopamine uptake inhibitor 3 alpha-[bis(4'-fluorophenyl)metoxy]-tropane reduces cocaine-induced early-gene expression, locomotor activity, and conditioned reward.

Clara Velázquez-Sánchez et al.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 34(12), 2497-2507 (2009-07-17)

Benztropine (BZT) analogs, a family of high-affinity dopamine transporter ligands, are molecules that exhibit pharmacological and behavioral characteristics predictive of significant therapeutic potential in cocaine addiction. Here, we examined in mice the effects of 3 alpha-[bis(4'-fluorophenyl)metoxy]-tropane (AHN-1055) on motor activity

N-substituted benztropine analogs: selective dopamine transporter ligands with a fast onset of action and minimal cocaine-like behavioral effects.

Su-Min Li et al.

The Journal of pharmacology and experimental therapeutics, 336(2), 575-585 (2010-11-23)

Previous studies suggested that differences between the behavioral effects of cocaine and analogs of benztropine were related to the relatively slow onset of action of the latter compounds. Several N-substituted benztropine analogs with a relatively fast onset of effects were

Therapeutic-like properties of a dopamine uptake inhibitor in animal models of amphetamine addiction.

Clara Velazquez-Sanchez et al.

The international journal of neuropsychopharmacology, 14(5), 655-665 (2010-08-26)

N-substituted benztropine (BZT) analogs are molecules that display high affinity for the dopamine transporter (DAT), therapeutic-like effects in animal models of cocaine abuse, and psychopharmacological characteristics consistent with those of a substitute medication for cocaine addiction. Since amphetamine (Amph) and

A dopamine transport inhibitor with markedly low abuse liability suppresses cocaine self-administration in the rat.

Antonio Ferragud et al.

Psychopharmacology, 207(2), 281-289 (2009-09-17)

N-substituted benztropine analogs are potent dopamine uptake inhibitors that display pharmacokinetic/dynamic properties consistent with the profile of a substitute medication for cocaine addiction. The purpose of the present experiments was to characterize in rats the addictive-like properties of one such

Assessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: comparisons with monoamine uptake inhibitors.

Takato Hiranita et al.

The Journal of pharmacology and experimental therapeutics, 329(2), 677-686 (2009-02-21)

Benztropine (BZT) analogs inhibit dopamine uptake but are less effective than cocaine in producing behavioral effects predicting abuse liability. The present study compared reinforcing effects of intravenous BZT analogs with those of standard monoamine uptake inhibitors and the effects of

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