471844
(1R)-(−)-(1-Aminohexyl)phosphonic acid
98%
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About This Item
Formule empirique (notation de Hill) :
C6H16NO3P
Numéro CAS:
Poids moléculaire :
181.17
Numéro MDL:
Code UNSPSC :
12352103
Essai
98%
Activité optique
[α]20/D −25°, c = 5 in 1 M NaOH
Pf
270-276 °C (lit.)
Chaîne SMILES
CCCCC[C@H](N)P(O)(O)=O
Application
Serves as an attractive substitute for amino carboxylic acids in biological systems. Exhibits interesting and useful properties as peptide analog, antiviral agent, hapten for the generation of catalytic antibodies, enzyme inhibitors, potent antibiotics, herbicides, and pesticides.
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M C Allen et al.
Journal of medicinal chemistry, 32(7), 1652-1661 (1989-07-01)
The synthesis of five amino phosphorus derivatives, 1a-e, is described. The derivatives were incorporated into a series (18) of analogues of the 5-14 portion of angiotensinogen, in most cases at the scissile Leu-Val bond. The resultant compounds were tested in
Camp, N.P. et al.
Bioorganic & Medicinal Chemistry Letters, 2, 1047-1047 (1992)
J Bird et al.
Journal of medicinal chemistry, 37(1), 158-169 (1994-01-07)
The synthesis of a series of N-phosphonalkyl dipeptides 6 is described. Syntheses were devised that allowed the preparation of single diastereoisomers and the assignment of stereochemistry. The compounds were evaluated in vitro for their ability to inhibit the degradation of
G Lavielle et al.
Journal of medicinal chemistry, 34(7), 1998-2003 (1991-07-01)
A series of new amino phosphonic acid derivatives of vinblastine (1, VLB) has been synthesized and tested in vitro and in vivo for antitumor activity. The compounds were obtained from O4-deacetyl-VLB azide. All of the new products studied were capable
F R Atherton et al.
Journal of medicinal chemistry, 29(1), 29-40 (1986-01-01)
Phosphonodipeptides and phosphonooligopeptides based on L- and D-(1-aminoethyl)phosphonic acids L-Ala(P) and D-Ala(P) and (aminomethyl)phosphonic acid Gly(P) at the acid terminus have been synthesized and investigated as antibacterial agents, which owe their activity to the inhibition of bacterial cell-wall biosynthesis. A
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