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148229

Sigma-Aldrich

Thiobenzamide

98%

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About This Item

Formule linéaire :
C6H5CSNH2
Numéro CAS:
2227-79-4
Poids moléculaire :
137.20
Numéro Beilstein :
606021
Numéro CE :
218-765-6
Numéro MDL:
MFCD00008060
Code UNSPSC :
12352100
ID de substance PubChem :
24848890
Nomenclature NACRES :
NA.22

Pureté

98%

Pf

113-117 °C (lit.)

Chaîne SMILES 

NC(=S)c1ccccc1

InChI

1S/C7H7NS/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9)

Clé InChI

QIOZLISABUUKJY-UHFFFAOYSA-N

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Application

Thiobenzamide was used to prepare amide and amidine adducts. It was also used in the synthesis of 4-oxo-4H-chromene-3-carbothioic acid N-phenylamides.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301

Classification des risques

Acute Tox. 3 Oral

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificats d'analyse (COA)

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Thioacetamide

Yakov M Koen et al.
Chemical research in toxicology, 26(4), 564-574 (2013-03-08)
Thioacetamide (TA) has long been known as a hepatotoxicant whose bioactivation requires S-oxidation to thioacetamide S-oxide (TASO) and then to the very reactive S,S-dioxide (TASO2). The latter can tautomerize to form acylating species capable of covalently modifying cellular nucleophiles including
E Chieli et al.
Archives of toxicology, 64(2), 122-127 (1990-01-01)
The effect of acetone pretreatment (5% in drinking water for 10 days on rat liver metabolism and toxicity of thiobenzamide (TB) was investigated. Hepatic microsomes from acetone-pretreated rats showed a significant increase of TB-S-oxidation rate which, on the basis of
D R Doerge et al.
Biochemistry, 30(37), 8960-8964 (1991-09-17)
The mechanism of organosulfur oxygenation by peroxidases [lactoperoxidase (LPX), chloroperoxidase, thyroid peroxidase, and horseradish peroxidase] and hydrogen peroxide was investigated by use of para-substituted thiobenzamides and thioanisoles. The rate constants for thiobenzamide oxygenation by LPX/H2O2 were found to correlate with
J M Domagala et al.
Drug design and discovery, 15(1), 49-61 (1997-05-01)
Substituted 2,2'-dithiobisbenzamides and 2-benzisothiazolones were prepared and shown to possess low microM activity with high therapeutic indices against HIV-1, HIV-2 and SIV in cell culture. The mechanism of antiviral action was determined to be directed toward the nucleocapsid protein (NCp7)
A K Naidu et al.
Research communications in chemical pathology and pharmacology, 71(2), 175-188 (1991-02-01)
Earlier this laboratory recognized lipoxygenase catalyzed reactions as a novel pathway for xenobiotic metabolism. To further explore the spectrum of reactions catalyzed by lipoxygenase, sulfoxidation of thiobenzamide was studied. Purified soybean lipoxygenase was found to oxidize thiobenzamide to thiobenzamide sulfoxide
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