11970
1,3-Diphenyl-2-propenone
≥98.0% (GC)
Synonyme(s) :
Benzalacetophenone, Chalcone
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About This Item
Formule linéaire :
C6H5CH=CHCOC6H5
Numéro CAS:
Poids moléculaire :
208.26
Beilstein:
1210466
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352100
ID de substance PubChem :
Nomenclature NACRES :
NA.22
Produits recommandés
Essai
≥98.0% (GC)
Solubilité
dioxane: soluble 1 g/10 mL, clear, colorless
Groupe fonctionnel
ketone
phenyl
Chaîne SMILES
O=C(\C=C\c1ccccc1)c2ccccc2
InChI
1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+
Clé InChI
DQFBYFPFKXHELB-VAWYXSNFSA-N
Informations sur le gène
rat ... Ar(24208)
Application
1,3-Diphenyl-2-propenone was used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines[1].
Actions biochimiques/physiologiques
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Équipement de protection individuelle
dust mask type N95 (US), Eyeshields, Gloves
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Hydroxysafflor yellow A (HSYA) is an active ingredient obtained from the flower of Carthamus tinctorius L. The present study investigated the effects of HSYA on lipopolysaccharide (LPS)-induced inflammatory signal transduction in human alveolar epithelial A549 cells. A549 cells stimulated with
Yau-Hung Chen et al.
Molecules (Basel, Switzerland), 18(2), 2052-2060 (2013-02-07)
The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line "Tg(mpx:gfp)" to visualize the effect of
Zijing Li et al.
Journal of medicinal chemistry, 56(2), 471-482 (2012-12-18)
Rhenium and technetium-99m cyclopentadienyl tricarbonyl complexes mimicking the chalcone structure were prepared. These complexes were proved to have affinity to β-amyloid (Aβ) in fluorescent staining on brain sections of Alzheimer's Disease (AD) patient and binding assay using Aβ(1-42) aggregates, with
Conventional and Microwave assisted Synthesis of 1, 3- Diphenyl -2- Propenone derivatives and Cytotoxic, Anti bacterial activites.
Ahmad MR and Bano N.
International Journal of ChemTech Research, 3(3), 1470-1478 (2011)
Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones.
Jeanne A Geyer et al.
Bioorganic & medicinal chemistry letters, 19(7), 1982-1985 (2009-03-03)
The cyclin dependent protein kinases, Pfmrk and PfPK5, most likely play an essential role in cell cycle control and differentiation in Plasmodium falciparum and are thus an attractive target for antimalarial drug development. Various 1,3-diaryl-2-propenones (chalcone derivatives) which selectivity inhibit
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