SMAD2
SMAD family member 2
Synonymes:
JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2
Espèce(s):
Human SMAD2 (4087), Mouse Smad2 (17126), Rat Smad2 (29357), dog SMAD2 (480144), domestic cat SMAD2 (101087179), Zebrafish smad2 (30639), chicken SMAD2 (395247), naked mole-rat Smad2 (101714203), domestic guinea pig Smad2 (100726958), sheep SMAD2 (101114231) ...Plus
ID UniProtKB:
ID du gène:
- Human(4087) Summary: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
- Mouse(17126) SMAD family member 2
- Rat(29357) SMAD family member 2
- dog(480144) SMAD family member 2
- domestic cat(101087179) SMAD family member 2
- Zebrafish(30639) MAD homolog 2 (Drosophila)
- chicken(395247) SMAD family member 2
- naked mole-rat(101714203) SMAD family member 2
- domestic guinea pig(100726958) SMAD family member 2
- sheep(101114231) SMAD family member 2
- sheep(443170) SMAD family member 2
- cow(516010) SMAD family member 2
- Horse(100033843) SMAD family member 2
- Domestic Rabbit(100359137) SMAD family member 2
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-Smad2/3 Antibody, Upstate®, from rabbit,
Espèces réactives
human, mouse, rat
Application
western blot
Monoclonal Anti-SMAD2 antibody produced in mouse, clone 3G6, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho SMAD2 Antibody (Ser465/467), from rabbit, purified by affinity chromatography,
Espèces réactives
xenopus, bovine, chicken, human, mouse, rat, zebrafish
Application
western blot
Anti-Phospho-Smad2-S465/467 + Smad3-S423/425 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anticorps anti-phospho-Smad2 (Ser465/467), clone A5S, monoclonal de lapin, culture supernatant, clone A5S, Upstate®,
Espèces réactives
canine, human, mouse, zebrafish
Application
western blot
Proteins
Référence du produit
Description
Espèce(s)
SMAD2, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human
esiRNA
Référence du produit
Description
Espèce(s)