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Merck

FAS

Fas cell surface death receptor

Synonymes:
ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
Espèce(s):
Human FAS (355), Mouse Fas (14102), Rat Fas (246097), fruit fly fas (36521), Zebrafish fas (768248), chicken FAS (395274), dog FAS (486469), domestic cat FAS (493881), Horse FAS (100071639), cow FAS (282488) ...Plus
ID UniProtKB:
P25445, A9UJX4, B6VNV4, Q14292, Q14293, Q14294, Q14295, Q16652
ID du gène:
  • Human(355) Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
  • Mouse(14102) Fas (TNF receptor superfamily member 6)
  • Rat(246097) Fas cell surface death receptor
  • fruit fly(36521) faint sausage
  • Zebrafish(768248) Fas (TNF receptor superfamily, member 6)
  • chicken(395274) Fas (TNF receptor superfamily, member 6)
  • dog(486469) Fas (TNF receptor superfamily, member 6)
  • domestic cat(493881) Fas (TNF receptor superfamily, member 6)
  • Horse(100071639) Fas (TNF receptor superfamily, member 6)
  • cow(282488) Fas (TNF receptor superfamily, member 6)
  • sheep(100144426) Fas (TNF receptor superfamily, member 6)
  • Domestic Rabbit(100008609) Fas (TNF receptor superfamily, member 6)
  • domestic guinea pig(100726403) Fas cell surface death receptor
  • naked mole-rat(101704746) Fas cell surface death receptor

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ELISA

Référence du produit
Description
Espèce(s)
RAB0177
Human Fas ELISA Kit, for cell and tissue lysates,
Espèce(s)
mouse
RAB0176
Human Fas ELISA Kit, for serum, plasma, cell culture supernatant and urine,
Espèce(s)
mouse
RAB0784
Mouse Fas ELISA Kit, ,
Espèce(s)
mouse
RAB0893
Rat Fas / Tumor Necrosis Factor Receptor Superfamily Member 6 ELISA Kit, ,
Espèce(s)
rat

Antibodies

Référence du produit
Description
Espèces réactives
Application
05-338
Anti-Fas Antibody (human, neutralizing), clone ZB4, clone ZB4, Upstate®, from mouse,
Espèces réactives
human
Application
flow cytometry
neutralization
western blot
05-201
Anticorps anti-Fas (humain, activant), clone CH11, clone CH11, Upstate®, from mouse,
Espèces réactives
human
Application
flow cytometry
immunocytochemistry
western blot
HPA027444
Anti-FAS antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
western blot
MAB3061
Anti-Fas Antibody, clone SM1/1, clone SM1/1, Chemicon®, from mouse,
Espèces réactives
human
Application
flow cytometry
SAB4501532
Anti-FAS antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
ELISA
immunofluorescence
western blot

Proteins

Référence du produit
Description
Espèce(s)
F2053
Fas Intracellular Domain human, >90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution,
Espèce(s)
human
SRP6480
Fas/CD95 human, recombinant, expressed in HEK 293 cells, ≥92% (SDS-PAGE),
Espèce(s)
human
SRP3037
FAS Receptor human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
Espèce(s)
human
F8799
Fas/Fc Chimera from mouse, >97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture,
Espèce(s)
mouse

esiRNA

Référence du produit
Description
Espèce(s)
EHU060231
MISSION® esiRNA, targeting human FAS,
Espèce(s)
human
EMU031961
MISSION® esiRNA, targeting mouse Fas,
Espèce(s)
mouse