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Merck

CYP2C9

cytochrome P450, family 2, subfamily C, polypeptide 9

Synonymes:
CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9
Espèce(s):
Human CYP2C9 (1559)
ID UniProtKB:
P11712, P11713, Q16756, Q16872, Q5VX92
ID du gène:
  • Human(1559) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

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Antibodies

Référence du produit
Description
Espèces réactives
Application
HPA015066
Anti-CYP2C9 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
western blot
SAB1305083
MONOCLONAL ANTI-CYP2C9 (N-TERMINAL) antibody produced in mouse, crude ascites, buffered aqueous solution,
Espèces réactives
human
Application
western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
T8904
Thiabendazole, ≥99%, powder,
Espèce(s)
human
T5535
Thiabendazole, suitable for plant cell culture,
Espèce(s)
human
M1390
3,3′-Methylene-bis(4-hydroxycoumarin), ,
Espèce(s)
human
S0758
Sulfaphenazole, ≥98%,
Espèce(s)
human
B5774
Benzbromarone, analytical standard,
Espèce(s)
human

Proteins

Référence du produit
Description
Espèce(s)
MTOXCE2C9
CypExpress™ 2C9 Cytochrome P450 human, ,
Espèce(s)
human
H4667
Cytochrome P450 2C9*2 (R144C), human, recombinant, expressed in E. coli,
Espèce(s)
human
H4542
Cytochrome P450 2C9*3 (I359L), human, recombinant, expressed in E. coli,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
EHU111841
MISSION® esiRNA, targeting human CYP2C9,
Espèce(s)
human

Small Molecule - Substrate

Référence du produit
Description
Espèce(s)
T0891
Tolbutamide, analytical standard,
Espèce(s)
human, mouse