The solubility of this USP standard has not been determined. Various sources note that this material is soluble at 0.885 mg/mL in water. In addition, PBS at pH 3.2 and 0.01 M HCl are listed, with no concentration reported. Please see the links below to review additional information that may be helpful:
https://pubs.acs.org/doi/10.1021/acs.jced.0c00047#
https://go.drugbank.com/drugs/DB00402
https://patents.google.com/patent/EP1997482A1/en
1255850
USP
Eszopiclone
United States Pharmacopeia (USP) Reference Standard
Synonym(s):
(+)-Eszopiclone, (+)-(5S)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate, (S)-Zopiclone
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About This Item
Empirical Formula (Hill Notation):
C17H17ClN6O3
CAS Number:
Molecular Weight:
388.81
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24
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Recommended Products
grade
pharmaceutical primary standard
API family
eszopiclone
manufacturer/tradename
USP
drug control
USDEA Schedule IV
application(s)
pharmaceutical (small molecule)
format
neat
SMILES string
Clc1cnc(cc1)N2[C@H](c4nccnc4C2=O)OC(=O)N3CCN(CC3)C
InChI
1S/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-14)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3/t16-/m0/s1
InChI key
GBBSUAFBMRNDJC-INIZCTEOSA-N
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Eszopiclone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Eszopiclone Tablets
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Other Notes
Sales restrictions may apply.
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Description
Pricing
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2 - STOT SE 3
Target Organs
Central nervous system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Hi. What is the solubility of Eszopiclone in water and PBS?
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