T9514
Tetrahydropapaverine hydrochloride
≥90%, powder
Synonym(s):
6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
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About This Item
Empirical Formula (Hill Notation):
C20H25NO4 · HCl
CAS Number:
Molecular Weight:
379.88
EC Number:
MDL number:
UNSPSC Code:
12352200
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Assay
≥90%
form
powder
color
white
solubility
H2O: soluble
storage temp.
2-8°C
SMILES string
Cl.COc1ccc(CC2NCCc3cc(OC)c(OC)cc23)cc1OC
Biochem/physiol Actions
Phosphodiesterase inhibitor.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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S Hosztafi et al.
Pharmacological research, 32(1-2), 15-20 (1995-07-01)
This review surveys the discovery of endogenous alkaloids in mammals. The formation of morphine in mammalian brain was assumed in 1970. The existence of morphine was demonstrated by radioimmunoassay. Identification of morphine was performed by spectroscopic methods. The isolation of
I Koshimura et al.
Brain research, 773(1-2), 108-116 (1997-12-31)
We report the toxic effects of 3,4-dimethoxyphenylethylamine (DMPEA), and tetrahydropapaverine (THP) on the rat nigrostriatal system; THP is a tetrahydroisoquinoline compound which may be derived from DMPEA by conjugation of DMPEA and its oxidative metabolite, dimethoxyphenylacetaldehyde; both are potent inhibitors
K Suzuki et al.
Neurochemical research, 15(7), 705-710 (1990-07-01)
Since the discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism, it has been postulated that (a) MPTP-like toxin(s) such as 1,2,3,4-tetrahydroisoquinoline (TIQ) may induce Parkinson's disease. As the neuronal degeneration in MPTP-induced parkinsonism is thought to be caused by the inhibition of the
S Chulia et al.
British journal of pharmacology, 122(3), 409-416 (1997-11-14)
1. In the present work, the properties of 3-methyl isoquinoline, 3,4-dihydropapaverine, tetrahydropapaverine and tetrahydropapaveroline were compared with those of papaverine and laudanosine. The work includes functional studies on rat isolated aorta contracted with noradrenaline, caffeine or KCl, and a determination
K Suzuki et al.
Advances in neurology, 53, 215-218 (1990-01-01)
Effects of MPTP-like compounds on mitochondrial respiration, activity of NADH-ubiquinone oxidoreductase (complex I) and on ATP synthesis were reported. Mitochondria prepared from mouse whole brains were used. The compounds tested include tetrahydroisoquinoline (TIQ), tetrahydropapaveroline (THP), tetrahydropapaverine (THPV), and salsolinol. TIQ
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