T2455

T3MG

• Synonym(s): (±)-threo-3-Methylglutamic acid, 3MG, threo-3-Methylglutamate
• Empirical Formula (Hill Notation): C₆H₁₁NO₄
• CAS Number: 63088-04-0
• Molecular Weight: 161.16
• MDL number: MFCD09836097
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826708
• NACRES: NA.77

Properties

• form: powder
• color: white to off-white
• solubility: H₂O: >1.5 mg/dL
• suitability: suitable for TLC (single spot)
• storage temp.: room temp
• SMILES string: C[C@@H](CC(O)=O)[C@@H](N)C(O)=O
• InChI: 1S/C6H11NO4/c1-3(2-4(8)9)5(7)6(10)11/h3,5H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,5+/m0/s1
• InChI key: FHJNAFIJPFGZRI-WVZVXSGGSA-N

Description

Biochem/physiol Actions

T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.

Features and Benefits

This compound is featured on the Excitatory Amino Acid Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

T3MG dissolves in water at a concentration that is greater than 1.5 mg/ml.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable