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SML2891

Sigma-Aldrich

M871 trifluoroacetate

≥95% (HPLC)

Synonym(s):

Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide, TFA salt, M 871, TFA salt, M-871, TFA salt, Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Glu-His-Pro-Pro-Pro-Ala-Leu-Alal-Leu-Ala-NH2, TFA salt, WTLNSAGYLLGPEHPPPALALA-NH2, TFA salt

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About This Item

Empirical Formula (Hill Notation):
C108H163N27O28 · xC2HF3O2
Molecular Weight:
2287.61 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

lyophilized powder

color

white to off-white

storage temp.

−20°C

Biochem/physiol Actions

M871 is a type 2-selective galanin receptor antagonist (GalR2/GalR1 Ki = 13.1/410 nM by competitive binding against 0.1 nM porcine galanin using membranes from CHO expressing respective human receptors; GalR2/GalR1 Ki = 2.5/1.1 nM in case of rat galanin) that potently blocks 10 nM rat galanin-induced inositol phosphate production in human GalR2-expressing CHO cells (by 100% with 0.1, 1 or 10 nM M871). M871 is widely employed in cultures (0.1 nM-2.5 μM) and in mice and rats in vivo via ip., brain region- or other site-specific injections.
Selective galanin receptor type 2 (GalR2) antagonist with in vitro and in vivo efficacy.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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M871-A Novel Peptide Antagonist Selectively Recognizing the Galanin Receptor Type 2
Sollenberg UE, Lundstrom L, Bartfai T, Langel U
International Journal of Peptide Research and Therapeutics, 12, 115-119 (2006)
Jesus-Servando Medel-Matus et al.
Experimental neurology, 289, 64-72 (2016-12-26)
Status epilepticus (SE) in rats, along with chronic epilepsy, leads to the development of behavioral impairments resembling depressive disorder and/or attention deficit/hyperactivity disorder (ADHD), thus reflecting respective comorbidities in epilepsy patients. Suppressed neurotransmitter tone in the raphe nucleus (RN)-prefrontal cortex
Seu-Hwa Chen et al.
PloS one, 13(6), e0199512-e0199512 (2018-06-22)
In this study, we investigated temporal changes in galanin receptor type 2 (GalR2) expression in NF200-, galanin-, neuropeptide Y (NPY)-, and neuronal nitric oxide synthase (nNOS)-like immunoreactive (LI) dorsal root ganglion (DRG) neurons after median nerve chronic constriction injury (CCI)
Pawel A Kolodziejski et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1863(10), 1228-1236 (2018-10-12)
Spexin (SPX, NPQ) is a novel peptide involved in the regulation of energy metabolism. SPX inhibits food intake and reduces body weight. In obese humans, SPX is the most down-regulated gene in fat. Therefore, SPX might be involved in the
Penghua Fang et al.
Biochemical pharmacology, 156, 241-247 (2018-09-01)
Although recent results of our and other studies have showed that galanin (GAL) is an antidiabetic and anti-inflammatory neuropeptide, the molecular mechanism how central GAL regulates energy homeostasis and insulin sensitivity is still not fully understood. The aim of this
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