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SML2289

Sigma-Aldrich

HBT1

Synonym(s):

2-(((5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetyl)amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, N-[3-(Aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]-5-methyl-3-(trifluoromethyl)-1H-pyrazole-1-acetamide

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5 MG
€74.20
25 MG
€241.00

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5 MG
€74.20
25 MG
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About This Item

Empirical Formula (Hill Notation):
C16H17F3N4O2S
CAS Number:
489408-02-8
Molecular Weight:
386.39
MDL number:
MFCD02053612
UNSPSC Code:
12352200
NACRES:
NA.77

€74.20

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Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(N)C1=C(NC(CN2C(C)=CC(C(F)(F)F)=N2)=O)SC3=C1CCCC3

InChI

1S/C16H17F3N4O2S/c1-8-6-11(16(17,18)19)22-23(8)7-12(24)21-15-13(14(20)25)9-4-2-3-5-10(9)26-15/h6H,2-5,7H2,1H3,(H2,20,25)(H,21,24)

InChI key

PHLXSNIEQIKENK-UHFFFAOYSA-N

Biochem/physiol Actions

AMPA-R potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons
HBT1 is an AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Akiyoshi Kunugi et al.
The Journal of pharmacology and experimental therapeutics, 364(3), 377-389 (2018-01-05)
α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor (AMPA-R) potentiators with brain-derived neurotrophic factor (BDNF)-induction potential could be promising as therapeutic drugs for neuropsychiatric and neurologic disorders. However, AMPA-R potentiators such as LY451646 have risks of narrow bell-shaped responses in pharmacological effects, including in

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