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SML1031

Sigma-Aldrich

Bioymifi

≥98% (HPLC)

Synonym(s):

(Z)-5-(5-[(3-[4-Bromophenyl]-2-imino-4-oxothiazolidin-5-ylidene)methyl]furan-2-yl)isoindoline-1,3-dione

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5 MG
€77.70
25 MG
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About This Item

Empirical Formula (Hill Notation):
C22H12BrN3O4S
CAS Number:
1420071-30-2
Molecular Weight:
494.32
UNSPSC Code:
12352200
NACRES:
NA.77

€77.70

Please contact Customer Service for Availability
Request a Bulk Order

Assay

≥98% (HPLC)

form

powder

color

, orange to dark orange red

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

S1\C(=C/c3[o]c(cc3)c4cc5c(cc4)C(=O)NC5=O)\C(=O)N(C1=N)c2ccc(cc2)Br

InChI

1S/C22H12BrN3O4S/c23-12-2-4-13(5-3-12)26-21(29)18(31-22(26)24)10-14-6-8-17(30-14)11-1-7-15-16(9-11)20(28)25-19(15)27/h1-10,24H,(H,25,27,28)/b18-10-,24-22?

InChI key

ULBOWKXOFOTCMU-NLDKGBHCSA-N

Biochem/physiol Actions

Bioymifi induces apoptosis via the Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) death receptor DR5 independent of TRAIL.
Bioymifi induces apoptosis via the Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) death receptor DR5 independent of TRAIL. Bioymifi binds selectively to the extracellular domain of DR5 with little binding affinity to DR4, promoting DR5 aggregation and activation. Bioymifi caused apoptosis and cell death in a variety of human cancer cell lines including T98G human glioblastoma cells, lung cancer cell lines H460 and H1155, the cervical cancer cell line HeLa, the osteosarcoma cell line U2OS, the pancreatic carcinoma cell line Miapaca and the colon cancer cell line HT29.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
044M4611V

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Articles

Discover Bioactive Small Molecules for Cell Cycle

Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

Bioactive Molecules for Apoptosis

Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.

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