SMB01026

Mosloflavon

≥90% (LC/MS-ELSD)

• Synonym(s): 5-Hydroxy-6,7-dimethoxyflavone
• Empirical Formula (Hill Notation): C₁₇H₁₄O₅
• CAS Number: 740-33-0
• Molecular Weight: 298.29
• MDL number: MFCD00601540
• UNSPSC Code: 12352205
• NACRES: NA.25

Properties

• biological source: plant
• Assay: ≥90% (LC/MS-ELSD)
• form: solid
• mol wt: 298.29
• solubility: water: slightly soluble
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: −20°C
• SMILES string: [o]1c2c([c](cc1c3ccccc3)=O)c(c(c(c2)OC)OC)O
• InChI: 1S/C17H14O5/c1-20-14-9-13-15(16(19)17(14)21-2)11(18)8-12(22-13)10-6-4-3-5-7-10/h3-9,19H,1-2H3
• InChI key: SIVAITYPYQQYAP-UHFFFAOYSA-N

Description

General description

Mosloflavon, a 2-hydroxyflavanone, is a bioactive natural compound commonly derived from plants such as Mosla soochouensis, Desmos dumosus, Muntingia calabura, Cryptocarya chinensis, and Phonus arborescens. Extensive research indicates that this natural metabolite acts as an inhibitor may possess a wide range of biological activities, including anti-inflammatory, antioxidant, antiviral, antifungal, immunomodulatory, anti-infection, and anti-hypoxic properties.

Application

Mosloflavon is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Biochem/physiol Actions

Mosloflavanone exhibits potent anti-EV71 activity by reducing visible cytopathic effects and suppressing virus replication during the initial infection phase. It also hinders the expression of the viral VP2 protein, thereby impeding viral capsid protein synthesis. Additionally, Mosloflavone demonstrates significant anti-inflammatory potential through the inhibition of TNF-α and IL-1β, with IC50 values of 16.4 μM and 6.4 μM, respectively. It shows a dose-dependent reduction in TNF-α, IL-1β, and iNOS levels in the supernatant of the mouse macrophage cell line J774A. This compound holds promise as a foundational element in the quest for treatments targeting inflammatory and immunomodulatory diseases.

Features and Benefits

• Suitable for Biochemical and Biomedical research
• Versatile and adaptable for wide variety of laboratory and research applications

Other Notes

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Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable