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About This Item
Empirical Formula (Hill Notation):
C99H126N20O33S1
Molecular Weight:
2156.24
UNSPSC Code:
12352209
NACRES:
NA.32
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![[Leu15,Gly18]-Gastrin2-17](/deepweb/assets/sigmaaldrich/product/images/384/185/d3095ca6-fe9a-4e1c-b2e9-29ad2bd40c46/640/d3095ca6-fe9a-4e1c-b2e9-29ad2bd40c46.jpg)
Assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥68%
storage condition
protect from light
storage temp.
−20°C
Amino Acid Sequence
Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-Gly
Application
Gastrin is a linear polypeptide that induces the secretion of gastric acid (HCl) by parietal cells. Gastrin is found in three major forms: gastrin-34 (big gastrin); gastrin-17 (little gastrin) and gastrin-13 minigastrin.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Suzana Kovac et al.
Biochimica et biophysica acta, 1813(5), 889-895 (2011-02-16)
The peptide hormone gastrin has been identified as a major regulator of acid secretion and a potent mitogen for normal and malignant gastrointestinal cells. The importance of gastric acid in the absorption of dietary iron first became evident 50 years
J F Rehfeld
Acta physiologica (Oxford, England), 201(4), 405-411 (2011-03-12)
Gastrin and cholecystokinin (CCK) are homologous hormone systems known to regulate gastric acid secretion, gallbladder emptying, and cell growth in the pancreas and stomach. They are, however, also involved in the development and secretory functions of pancreatic islet cells. For
Gastrin in gastrointestinal diseases.
Daniel Fourmy et al.
Gastroenterology, 141(3), 814-818 (2011-07-20)
Mitchell L Schubert
Current opinion in gastroenterology, 27(6), 536-542 (2011-09-08)
The review summarizes the past year's literature regarding the regulation of gastric exocrine and endocrine secretion, both basic science and clinical. Gastric acid secretion is an elaborate and dynamic process that is regulated by neural (efferent and afferent), hormonal (e.g.
Sara Calatayud et al.
Mini reviews in medicinal chemistry, 10(1), 8-19 (2010-04-13)
Gastrin release is affected by gastric inflammatory conditions. Antral G cells respond to inflammatory mediators by increasing gastrin secretion. Accumulating experimental evidence suggests that gastrin exerts immunomodulatory and proinflammatory effects. Gastrin could be a contributing factor to these pathologies, which
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